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Database: UniProt
Entry: B8GE93_METPE
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Original site: B8GE93_METPE 
ID   B8GE93_METPE            Unreviewed;       560 AA.
AC   B8GE93;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   25-OCT-2017, entry version 47.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Mpal_2309 {ECO:0000313|EMBL:ACL17594.1};
OS   Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanomicrobiales;
OC   Methanoregulaceae; Methanosphaerula.
OX   NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL17594.1, ECO:0000313|Proteomes:UP000002457};
RN   [1] {ECO:0000313|EMBL:ACL17594.1, ECO:0000313|Proteomes:UP000002457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC   {ECO:0000313|Proteomes:UP000002457};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G.O., Zinder S.;
RT   "Complete sequence of Candidatus Methanosphaerula E1-9c.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP001338; ACL17594.1; -; Genomic_DNA.
DR   RefSeq; WP_012618913.1; NC_011832.1.
DR   STRING; 521011.Mpal_2309; -.
DR   EnsemblBacteria; ACL17594; ACL17594; Mpal_2309.
DR   GeneID; 7270570; -.
DR   KEGG; mpl:Mpal_2309; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   HOGENOM; HOG000225809; -.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000002457; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002457};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000002457};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:ACL17594.1}.
FT   DOMAIN        8    277       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      325    451       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       156    156       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     266    266       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     280    280       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   560 AA;  61687 MW;  86FB387D81D065DD CRC64;
     MAKIERSQKL FLKALKEKFA GEDPAGEHTH FARAGLEQSE RKREFMKEGK KVEMERGISQ
     YDPKRCHLGG IPLGQRQLMT YEISGTGTFV EGDDLHFVNN AAMQQMWDDI RRTIIVGMDL
     AHNTLQKRLG KEVTPETINE YLHILNHAMP GAAVVQEHMV ETHPSLVSDC YVKVFTGDDE
     VADQIEPQYL LNIEKLFPAK SAEKLKAAVG KSMFQAIHIP TTVSRTCDGG TTSRWSAMQI
     GMSFIAAYRM CAGEAAVADL SYAAKHAGVI QMADILPARR ARGPNEPGGI KFGNFCDMIQ
     ADRKYPNDPA KASLEVVGAG TMLFDQIWLG SYMSGGVGFT QYATAAYTDN ILDEFVYYGM
     DYLKSKYGGY SQAPATQEVV NDLATEVTLN AMEQYEQFPT MMEDHFGGSQ RASVIAAASG
     LTTSIGTGNS NAGLNGWYLS MLMHKEGWSR LGFFGYDLQD QCGSANSMSI RPDEGLLGEL
     RGPNYPNYAM NVGHQGEYAA ISGGAHFGRG DPWVLNPLIK ITFADPSLVF DFSEPRREFA
     KGAIREFMPA GERSLIIPAR
//
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