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Database: UniProt
Entry: B8IZ14_DESDA
LinkDB: B8IZ14_DESDA
Original site: B8IZ14_DESDA 
ID   B8IZ14_DESDA            Unreviewed;       482 AA.
AC   B8IZ14;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   25-OCT-2017, entry version 72.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   OrderedLocusNames=Ddes_0833 {ECO:0000313|EMBL:ACL48741.1};
OS   Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=525146 {ECO:0000313|EMBL:ACL48741.1, ECO:0000313|Proteomes:UP000002598};
RN   [1] {ECO:0000313|EMBL:ACL48741.1, ECO:0000313|Proteomes:UP000002598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27774 / DSM 6949 {ECO:0000313|Proteomes:UP000002598};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L.,
RA   Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ovchinnikova G., Hazen T.C.;
RT   "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans
RT   str. ATCC 27774.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001358; ACL48741.1; -; Genomic_DNA.
DR   RefSeq; WP_012624466.1; NC_011883.1.
DR   ProteinModelPortal; B8IZ14; -.
DR   STRING; 525146.Ddes_0833; -.
DR   EnsemblBacteria; ACL48741; ACL48741; Ddes_0833.
DR   KEGG; dds:Ddes_0833; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; ASYYHIS; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DDES525146:GIWF-846-MONOMER; -.
DR   Proteomes; UP000002598; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002598};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002598}.
FT   DOMAIN      172    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      382    450       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   482 AA;  53156 MW;  FC34D8286F8C80BD CRC64;
     MRDKWAEISE NLKKMLKSGL FKVWIAPLHA SVHEGGLHLV APNAYVAGRL ESMMLASLRE
     AAAPVLGLEP EQVDVRIEAA EQSADAEIVE EKQSSMQKKP ADRADVSASA PSAVASFMAP
     ARAPRQASLP LPSVAVYRDT QNWRYSFADF VVGPTNNMAV AAAQDVSRSC GCVRTLFVNS
     SSGLGKTHLA QAVGRAISEE GTNARVGYLT AEEFASRFVT ALRAQDIEGF KARFRELDVL
     LMEDVHFFQG KEKMQDMALA VVKSLQAKGG RAIFTSSFSP RELQKVDSQL VSHFCSGILT
     DMGRPTKDMR CDILGRKART FQVLLPESVC DLLASRLTGD VRQMESCLNS LIFKARLLNC
     GLNVDLAMEV LSQYADVACG PDFSTILRLV CESYGLNERQ LSSRSRRKEC VVGRNTAFYL
     ARKHTEMTLE EIGEKFNRRH STVIKGITSL ERELSRESTE GRRIARAVSL IERNAGLAER
     PM
//
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