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Database: UniProt
Entry: B8J1G6_DESDA
LinkDB: B8J1G6_DESDA
Original site: B8J1G6_DESDA 
ID   B8J1G6_DESDA            Unreviewed;       457 AA.
AC   B8J1G6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   25-OCT-2017, entry version 69.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=Ddes_0003 {ECO:0000313|EMBL:ACL47923.1};
OS   Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=525146 {ECO:0000313|EMBL:ACL47923.1, ECO:0000313|Proteomes:UP000002598};
RN   [1] {ECO:0000313|EMBL:ACL47923.1, ECO:0000313|Proteomes:UP000002598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27774 / DSM 6949 {ECO:0000313|Proteomes:UP000002598};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L.,
RA   Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ovchinnikova G., Hazen T.C.;
RT   "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans
RT   str. ATCC 27774.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001358; ACL47923.1; -; Genomic_DNA.
DR   RefSeq; WP_012623655.1; NC_011883.1.
DR   STRING; 525146.Ddes_0003; -.
DR   EnsemblBacteria; ACL47923; ACL47923; Ddes_0003.
DR   KEGG; dds:Ddes_0003; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000227577; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DDES525146:GIWF-3-MONOMER; -.
DR   Proteomes; UP000002598; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 2.
DR   Pfam; PF00308; Bac_DnaA; 2.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002598};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002598}.
FT   DOMAIN      366    435       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   457 AA;  51587 MW;  0659B091CB6B8A76 CRC64;
     MLKKELREIL AENRATAGET WLESLTLRQE KDTLRVVFPH MYFADWFSLH RRAAFEDALR
     RHFTRLHEDS VPRIVYESAA PGAFAARTLP QPVSPPPGPD CRSNTMAEAE DPFADFICND
     KNAFPLATAR DLAADTTSTA YNPFLVCGRS GTGKSRLLQA MTCVMSRTAD PARMICSSAA
     RFCSEHLVWA RRPELFWLRY DVLVLDDIQD LAGHDAWQRK LVTIIDTCPG RQKNLPGIPS
     GEDIPSAGEQ IHRAAPRMIF ACSGQPQALK ALDERLRSRL ESGLVVELME PDLDVRLRYL
     QVICKERRLP LTREQLLFLA QRCSQFRLLQ GLMLKVGAYC AVKGNNLTQS DMENIVRTGV
     AEKMPGCREI LGEVARRLNL RPEDVLGAKR RPDLVLARQV SMYICRRKLG LSYPELGRAF
     GGRDHSTVIY AINKIKKLMV SNKSVHQLVT EIEMKTP
//
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