ID B8JJ92_MOUSE Unreviewed; 580 AA.
AC B8JJ92;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Apoptotic chromatin condensation inducer 1 {ECO:0000313|Ensembl:ENSMUSP00000022794.8};
GN Name=Acin1 {ECO:0000313|Ensembl:ENSMUSP00000022794.8,
GN ECO:0000313|MGI:MGI:1891824};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000022794.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:18630941}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [2] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000022794.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000022794.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000022794.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000022794.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; B8JJ92; -.
DR SMR; B8JJ92; -.
DR jPOST; B8JJ92; -.
DR MaxQB; B8JJ92; -.
DR PeptideAtlas; B8JJ92; -.
DR ProteomicsDB; 310501; -.
DR Antibodypedia; 63; 579 antibodies from 37 providers.
DR Ensembl; ENSMUST00000022794.14; ENSMUSP00000022794.8; ENSMUSG00000022185.20.
DR UCSC; uc011zle.1; mouse.
DR AGR; MGI:1891824; -.
DR MGI; MGI:1891824; Acin1.
DR VEuPathDB; HostDB:ENSMUSG00000022185; -.
DR GeneTree; ENSGT00710000106790; -.
DR ChiTaRS; Acin1; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000022185; Expressed in embryonic brain and 252 other cell types or tissues.
DR ExpressionAtlas; B8JJ92; baseline and differential.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd12432; RRM_ACINU; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034257; Acinus_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR032552; RSB_motif.
DR PANTHER; PTHR46589; APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS; 1.
DR PANTHER; PTHR46589:SF1; APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS; 1.
DR Pfam; PF16294; RSB_motif; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:B8JJ92,
KW ECO:0007829|MaxQB:B8JJ92};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..372
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 67113 MW; 9C6190B922EC976A CRC64;
MMFSDSRAGE EKEEVTMDTS ENRPENEVPE PPLPVADQVS NDERPEGGAE EEEKKESSMP
KSFKRKISVV STKGVQAGNS DTEGGQPGRK RRWGASTAAT QKKPSISITT ESLKSLIPDI
KPLAGQEAVV DLHADDSRIS EDETERNGDD GTHDKGLKIC RTVTQVVPAE GQENGQREEE
EEKEPEAELP APPQVSVEVA LPPPVEHEVK KVTLGDTLTR RSISQQKSGV SITIDDPVRT
AQVPSPPRGK ISNIVHISNL VRPFTLGQLK ELLGRTGTLV EEAFWIDKIK SHCFVTYSTV
EEAVATRTAL HGVKWPQSNP KFLCADYAEQ DELDYHRGLL VDRPSETKAE EQGAPRPLHP
PPPPPVQPPP HPRAEQREQE RAVREQWAER EREMERRERT RSEREWDRDK VREGPRSRSR
SRDRRRKERA KSKEKKSEKK EKAQEEPPAK LLDDLFRKTK AAPCIYWLPL TESQIVQKEA
EQAERAKERE KRRKEREEEE QKEREKEAER ERNRQLEREK RREHSRERER DRERERDRGD
RERERERDRD RGRERDRRDT KRHSRSRSRS TPVRDRGGRR
//
