ID   B8L151_9GAMM            Unreviewed;       400 AA.
AC   B8L151;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Cystathionine beta-lyase {ECO:0000313|EMBL:EED37054.1};
DE            EC=4.4.1.8 {ECO:0000313|EMBL:EED37054.1};
GN   Name=metC {ECO:0000313|EMBL:EED37054.1};
GN   ORFNames=SSKA14_60 {ECO:0000313|EMBL:EED37054.1};
OS   Stenotrophomonas sp. SKA14.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas.
OX   NCBI_TaxID=391601 {ECO:0000313|EMBL:EED37054.1};
RN   [1] {ECO:0000313|EMBL:EED37054.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SKA14 {ECO:0000313|EMBL:EED37054.1};
RA   Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; DS999412; EED37054.1; -; Genomic_DNA.
DR   RefSeq; WP_008264498.1; NZ_DS999412.1.
DR   AlphaFoldDB; B8L151; -.
DR   HOGENOM; CLU_018986_2_0_6; -.
DR   Proteomes; UP000003991; Unassembled WGS sequence.
DR   GO; GO:0004121; F:cystathionine beta-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:EED37054.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2}.
FT   MOD_RES         206
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   400 AA;  42576 MW;  4CBCF7B6AF4C1122 CRC64;
     MSHSSSPDRA LALATLAIHG GQSPDPSTGA VMPPIYATST YAQSSPGEHQ GFEYSRTHNP
     TRFAYERCVA SLEGGTRGFA FASGMAASST VIELLDAGSH VVAMDDIYGG SFRLFERVRR
     RTAGLDFSFV DLTDLAAFEA SITSKTKMVW IETPTNPMLK IVDIAAVAAI AKRHGLIVVV
     DNTFASPMLQ RPLELGADLV LHSATKYLNG HSDMVGGMVV VGDNAELAEQ MAFLQNSVGG
     VQGPFDSFLA LRGLKTLPLR MKAHCANALA LAQWLEKHPA VEKVIYPGLP SHPQHELAGK
     QMAGYGGIVS IVLKGGFEAA KRFCEKTELF TLAESLGGVE SLVNHPAVMT HASIPVARRE
     QLGISDALVR LSVGVEELGD LQVDLERALA PVGGTSRNGR
//