ID B8LVG5_TALSN Unreviewed; 415 AA.
AC B8LVG5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=Target of rapamycin complex subunit LST8 {ECO:0000256|ARBA:ARBA00018867};
GN ORFNames=TSTA_073700 {ECO:0000313|EMBL:EED23984.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED23984.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SIMILARITY: Belongs to the WD repeat LST8 family.
CC {ECO:0000256|ARBA:ARBA00009890}.
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DR EMBL; EQ962652; EED23984.1; -; Genomic_DNA.
DR RefSeq; XP_002341371.1; XM_002341330.1.
DR AlphaFoldDB; B8LVG5; -.
DR STRING; 441959.B8LVG5; -.
DR GeneID; 8105123; -.
DR VEuPathDB; FungiDB:TSTA_073700; -.
DR eggNOG; KOG0315; Eukaryota.
DR HOGENOM; CLU_000288_57_5_1; -.
DR InParanoid; B8LVG5; -.
DR OMA; VQRNYKH; -.
DR OrthoDB; 650241at2759; -.
DR PhylomeDB; B8LVG5; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037588; MLST8.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19842; G BETA-LIKE PROTEIN GBL; 1.
DR PANTHER; PTHR19842:SF0; TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 71..112
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 112..153
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 203..237
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 354..395
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 247..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 45069 MW; 65D4379A8B711821 CRC64;
MSVILCTAGY DHTIRFWEAL SGICSRTLQH PDSQVNRLCI TPDKRYLAAA GHTNVKLFDI
KSSNPNPVMT FEGHTNNITG VAFHCEGKWM VTSSEDGTVK VWDTRSGSLQ RNYVHKAPVN
DVVIHPNQGE LISGDRAGTV RVWDLGESVC THQLIPEDDV AVSSVSVASD GSLLCAGNKR
GNVYIWRMIQ DTEVTRIVPI AMFQAHRDYL TRVLLSPDVK HLATCSADHT AKIWNLDQAY
PPAVAAAAEA AASRPSNTNT TNTNGAATPS PNPPSNGVSS NGVTASPQPQ PSRSTSTDQA
ASDFSMVSSN HNLTLLPSIQ NQQQQQQQPN PFPTQPDGPP IDPSTGTPFL ETTLSGHQRW
VWDCAFSADS AYLVTVSSDH YARLWELASG TIIRQYSGHH RGAVCVALND YSEPR
//
