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Database: UniProt
Entry: B8LW08_TALSN
LinkDB: B8LW08_TALSN
Original site: B8LW08_TALSN 
ID   B8LW08_TALSN            Unreviewed;       857 AA.
AC   B8LW08;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TSTA_077370 {ECO:0000313|EMBL:EED24374.1};
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 /
OS   NRRL 1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=441959 {ECO:0000313|EMBL:EED24374.1, ECO:0000313|Proteomes:UP000001745};
RN   [1] {ECO:0000313|Proteomes:UP000001745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC   {ECO:0000313|Proteomes:UP000001745};
RX   PubMed=25676766; DOI=10.1128/genomeA.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; EQ962652; EED24374.1; -; Genomic_DNA.
DR   RefSeq; XP_002341761.1; XM_002341720.1.
DR   STRING; 441959.XP_002341761.1; -.
DR   EnsemblFungi; EED24374; EED24374; TSTA_077370.
DR   GeneID; 8101998; -.
DR   EuPathDB; FungiDB:TSTA_077370; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; B8LW08; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001745};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    550    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    580    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    647    666       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    780       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    792    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   857 AA;  97562 MW;  E62D9CDEF1C45EE4 CRC64;
     MAPKDTFFRS ADMSLTQLYI ANEIGREVVS ALGEVGQVQF RDLNPDTNAF QRTFTKEIRR
     LDNVERQLRY FASQMEKDNI TMRPSSEFGN TLAAPSSAEI DELAERSESL EQRIASLNDS
     YETLKKREME LTEWRWVLRE AGGFFDRAHG HTEEIRTSVD GESDDAPLLQ DVEHQVPGAQ
     NGDTQQSFSV MNIGFVAGVI PRERIGSFER ILWRTLRGNL YMNQSEIPEP IIDPATNEEI
     HKNVFVIFAH GKEILAKIRK ISESLGASLY GVDENSELRR DQIHEVNTRL GDVESVLRNT
     KNTLDAELTQ IARSLAAWMI IVKKEKAVYH TLNKFSYDQA RKTLIAEAWV PTNSLSLIKS
     TLQDVNDRAG LSVPTIVNQI RTNKTPPTYV KTNKFTEAFQ TIINAYGITK YSEVNPGLPT
     IITFPFLFAV MFGDFGHGFL MTLTATAMIL FEKTLLRTKL DELTYMAFYG RYIMLMMGIF
     SMYTGLIYND VFSLSFEIFP SQWQWPHNID EGQAVHATLK QGYRYPFGLD WNWHEAENAL
     LFTNSYKMKL SILMGWAHMT YSLSLQYINA RHFKSKVDIF GNFLPGMIFF QSIFGYLVFT
     IIYKWSVDWN ARGESPPGLL NMLIFMFLSP GTIEQQLYPG QAGVQKFLLG LAVLQVPIML
     LLKPLWLRRE HNRARGLGYQ GIGERAHVSA LDEDGDMNGR ASEGRDSMAS DGEGVAMIAQ
     DIDEGEHEEF DFADEMIHQV IHTIEFCLNC ISHTASYLRL WALSLAHQQL SIVLWTMTLG
     GSFGIESSTT RIIMIVVGFY LWFFLTVAIL CVMEGTSAML HSLRLHWVEA MSKHFIGDGI
     PFQPFSFKTL LEEDPVD
//
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