GenomeNet

Database: UniProt
Entry: B8M4A6_TALSN
LinkDB: B8M4A6_TALSN
Original site: B8M4A6_TALSN 
ID   B8M4A6_TALSN            Unreviewed;      1414 AA.
AC   B8M4A6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   13-SEP-2023, entry version 82.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN   ORFNames=TSTA_024270 {ECO:0000313|EMBL:EED19101.1};
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959 {ECO:0000313|EMBL:EED19101.1, ECO:0000313|Proteomes:UP000001745};
RN   [1] {ECO:0000313|Proteomes:UP000001745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC   {ECO:0000313|Proteomes:UP000001745};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC         isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC         Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC         ChEBI:CHEBI:456215; EC=6.1.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000114};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EQ962654; EED19101.1; -; Genomic_DNA.
DR   RefSeq; XP_002479535.1; XM_002479490.1.
DR   STRING; 441959.B8M4A6; -.
DR   GeneID; 8109609; -.
DR   VEuPathDB; FungiDB:TSTA_024270; -.
DR   eggNOG; KOG0433; Eukaryota.
DR   eggNOG; KOG1198; Eukaryota.
DR   HOGENOM; CLU_001493_7_2_1; -.
DR   InParanoid; B8M4A6; -.
DR   OMA; YHDHKST; -.
DR   OrthoDB; 656at2759; -.
DR   PhylomeDB; B8M4A6; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR   CDD; cd00818; IleRS_core; 1.
DR   CDD; cd08276; MDR7; 1.
DR   Gene3D; 1.10.730.20; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 1.10.10.830; Ile-tRNA synthetase CP2 domain-like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   HAMAP; MF_02002; Ile_tRNA_synth_type1; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR033708; Anticodon_Ile_BEm.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR023585; Ile-tRNA-ligase_type1.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT   DOMAIN          23..355
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   1414 AA;  157047 MW;  84911636CB5C4098 CRC64;
     MSSTYQAWHV YRNASTQSEK SLDILDNLVL EEIEKPVPGP GQVLVRIHAA ALNFRDLLIT
     AFSPKYPVPT TLGLSPCSDG AGAIEAVGPD NKIWNVGDEV IFRVSNSWDS GDVSNFKGNG
     IGSGDIHGTL SQYLVMDESW LVRKPTHLTW EHAASIAGAG GTAIQALFHN GISNGLDLSG
     KTVLTQGTGG SSIFCAQFAV AAGARVIGTT SSESKAELLK SLGVHEVVNY KIHPAWADEV
     LKLTEGRGVD LVIDVGGSAT FEQSLKAARF GGTVAAVGFL TEPQPSDPGL IHTIIFGAKT
     LRGQMAASLV MYHEMVELME KHKIEPVVGQ VFEWSAAKEA FKALMKQSVP GKIVIKVCQC
     GRSGTYGAMG FPIGQPSSMT RSWTSTLKLP RSSFPARVSV ADQAKYLRKC SDELYAWQRE
     NRPANETFVL HDGPPYANGE LHVGHSLNKI LKDIINRTQL SRGKRIHYVP GWDCHGLPIE
     LKALQAQQKN VIDFTQGPGS AATIRKAARK LAEKTVKEQM RVFRGFGIMA DWEGHWKTLD
     KGFEMKQLGI FREMVEKGLI YRRFKPVYWS PSTGTALAEA ELEYNDNHIS TAALVRFPLA
     KLPEQIRDKP LVDVTSLSAV IWTTTPWTLP ANAAIAVHES LNYLIVQSSN HGQLLIAESR
     LGYFQDMLKE ELQVLVPSIQ GSELCQKTTY RPLFPRDGVE EQPIIAADFV TADSGSGLVH
     CAPGHGMDDY EVCLAQGIQA FAPVTDEGCF TDEAMPRDPS FLSGKSVLDE GNTLVLQYVE
     SMSQLLCQHK YEHKYPYDWR SKRPIIIRAT EQWFADVANI RESALASLED VTFVPASGKQ
     RLKNFVQNRT EWCISRQRAW GVPIPALYDK VTGQAVLTKE TVSHIMNVID ERGIDAWWTD
     SPEDPAWIPP FLQQDGSSDY RRGTDTMDVW FDSGTSWTQV ENESLEKDRP ADIYLEGTDQ
     HRGWFQSSLL TYVAHQVASG KSDASTIKSP FKHLITHGFT LDQDARKMSK SIGNIIQPDA
     IMNGTLLPPL KQKKSKGTKE QKVSGPVYDA LGPDALRLWV ASSDYTRDVV IGQQVLQTIN
     TSLHKYRVTF KLLLGALGDF DPSVNLRQYE DLHKIDRLAL MQLTRLVDTC RNAFDSFEFY
     KAVNALNRWA NHEFSAFYME TLKDRLYTEA EDGASRRAAQ TTLFHIYTYL QELLAPITPL
     LVEESWEHTS ERVKAQLKHP LQRISRAAPA EWVDETTSHD FVDLMAANAA VKIIQESARS
     KKQMGSSLQS FVYFELRDES LGTFQRYISE LPDLFVVSSV SLGVKGSDLP GEIASAKWSY
     TQEFELPNSK QKATVHVYAP TQAKCPRCWR YAAPEAVAEE PPLCERYQCT IRGADKMKIR
     GNPSPYHIGA SPDQSNDVCI PTSERVQIAR IGLF
//
DBGET integrated database retrieval system