ID B8M6W5_TALSN Unreviewed; 852 AA.
AC B8M6W5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=TSTA_034240 {ECO:0000313|EMBL:EED20185.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED20185.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
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DR EMBL; EQ962654; EED20185.1; -; Genomic_DNA.
DR RefSeq; XP_002480619.1; XM_002480574.1.
DR AlphaFoldDB; B8M6W5; -.
DR STRING; 441959.B8M6W5; -.
DR GeneID; 8097840; -.
DR VEuPathDB; FungiDB:TSTA_034240; -.
DR eggNOG; KOG2230; Eukaryota.
DR HOGENOM; CLU_005015_1_1_1; -.
DR InParanoid; B8M6W5; -.
DR OMA; DWGPVIM; -.
DR OrthoDB; 2504097at2759; -.
DR PhylomeDB; B8M6W5; -.
DR UniPathway; UPA00280; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:EED20185.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EED20185.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 204..304
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 682..771
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 852 AA; 97974 MW; 3E06F70650BE611A CRC64;
MAFFEKRLST GWTFRDVDDE GSDAWMPVPS IPSTAQQDLI ANNKLENPYI GFNELKARWV
NEKSWIYRHE FEQPEIPADA TVALVFDGLD TFASVTLDGQ KILESDNMFM GYRVNITDIL
IAKGPHVLEI KFDCAQFRAR EIRSQHPDHK WVGFNGDMAR LAVRKAQYHW GWDWGPVIMT
AGIWREVRLE VYSARVADLW PQITSISSDH QKASVTMIAK IDAAGILESC TASFRLTLRG
QELAHQDNIS VNATDQTVQA EFQLTNPELW WPHGYGSQTL YEVSISLWSN GKELHKKSKR
FGIRSAEVIQ QPDKHGKSFF FRINGVDIFC GGSCWIPTDS LLPSITAERY RKWIELMVAG
GQMMIRVWGG GIYEDDRFYE VCDELGVLVW QDFMFGCGNY PVWPRMRESI RQEAIYNVQR
LRHHPSIVIY VGNNEDYQVQ EQAKLTYHYD DKNPENWLKT DFPARYIYEK ILLEVVAEHS
PGTFYHPGSP WGDGKITSDP TVGDMHQWNV WHGSQEKYQI FASLGGRFNS EFGMEAFPHM
STIEYFVENE ADKFPQSHVL DFHNKADGHE RRLATYLVEN VRTATDLETY IYLTQVIQAE
TMMFGYTGWR RQWGDERHCG GALLWQLNDC WPTISWSIVD YFLRPKPAYY TVKRALKSVA
IGVRREHHDW SVVHAQPPTS SRYDVWIASS RQEVLRGKVE LRFISVVSGE ELRSAMIFED
IVIKPNGTTN VLTNGMIDHI AEPEPHVLSA RLWVGGDIVA RDIDWPQPFK YLDFSDRGLE
VKPETRTSST GEKQQILKIS AQRPVKCLVF EERDNVRLSD SAMDIVPGDE QVVIVTGLDE
SSAPLKYRYL GQ
//
