ID B8M745_TALSN Unreviewed; 575 AA.
AC B8M745;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Patatin-like serine hydrolase, putative {ECO:0000313|EMBL:EED20265.1};
GN ORFNames=TSTA_034950 {ECO:0000313|EMBL:EED20265.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED20265.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR EMBL; EQ962654; EED20265.1; -; Genomic_DNA.
DR RefSeq; XP_002480699.1; XM_002480654.1.
DR AlphaFoldDB; B8M745; -.
DR STRING; 441959.B8M745; -.
DR GeneID; 8104337; -.
DR VEuPathDB; FungiDB:TSTA_034950; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_5_0_1; -.
DR InParanoid; B8M745; -.
DR OMA; SIVPWPH; -.
DR OrthoDB; 154387at2759; -.
DR PhylomeDB; B8M745; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR CDD; cd07229; Pat_TGL3_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EED20265.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 187..377
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 575 AA; 65480 MW; A0291907136F841B CRC64;
MPLLTLGAKL WSLSAAIVGM ILDVLQFWNY RWMLWLRSRS PKDQLSYALA RADTFEEWEE
TAFRLDELTS ADLWRQNPTS KHYDYRLILQ RLESILSARE SEDILTLVSI LRSGLVRNLG
NITSMRLFNH AYTGTKLLID DYITHVALSI QYVTSLQTMP MHVSGFTSQA KLELLHDTRQ
AFGRTSLVLQ GGSIFGLCHL GVVKALHLRG LLPRIITGTA TGALVAALVG VRTEDELLDF
LDSDILEYCV FEGQSQKGKW KGKGSTTHNE QSRIGFGRLR RYFVEGNFLD ESVLEECVRT
YVGDMTFEEA YAKTKRILNV TVAASVKGAF PNLLNYLTAP NVLIRSATLA SNASSETLHC
KDETGAIVPW PHTQDVTFRS WRQVNLSGRE SPLARLAELF NVNHFIVSQT RPYIVPFLYP
DTHPGQRNSN HPSLNRPLMR LIMLEMRHRL RQLDYLGFLP MSLRRLLMDE NIPGPSLTLI
PDLTTSDFLK LFQAPSKAGL DYWIRKGERG VWPAVSALRV RCAIEIELDR CYQMVRRRRR
RSDVSQQPAV VPHYRHGANE GVLRKRRSIG HESVE
//
