ID B8M7J5_TALSN Unreviewed; 410 AA.
AC B8M7J5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Ribonuclease H2 subunit B {ECO:0000256|ARBA:ARBA00019062};
DE AltName: Full=Ribonuclease HI subunit B {ECO:0000256|ARBA:ARBA00033464};
GN ORFNames=TSTA_028370 {ECO:0000313|EMBL:EED19548.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED19548.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC replication, possibly by mediating the removal of lagging-strand
CC Okazaki fragment RNA primers during DNA replication. Mediates the
CC excision of single ribonucleotides from DNA:RNA duplexes.
CC {ECO:0000256|ARBA:ARBA00024778}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; EQ962654; EED19548.1; -; Genomic_DNA.
DR RefSeq; XP_002479982.1; XM_002479937.1.
DR AlphaFoldDB; B8M7J5; -.
DR STRING; 441959.B8M7J5; -.
DR GeneID; 8108353; -.
DR VEuPathDB; FungiDB:TSTA_028370; -.
DR eggNOG; ENOG502SCDS; Eukaryota.
DR HOGENOM; CLU_057573_0_0_1; -.
DR InParanoid; B8M7J5; -.
DR OMA; YYFCPKL; -.
DR OrthoDB; 2100348at2759; -.
DR PhylomeDB; B8M7J5; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032299; C:ribonuclease H2 complex; IEA:InterPro.
DR CDD; cd09270; RNase_H2-B; 1.
DR Gene3D; 1.10.20.120; -; 1.
DR InterPro; IPR040456; RNase_H2_suB.
DR InterPro; IPR019024; RNase_H2_suB_wHTH.
DR InterPro; IPR041195; Rnh202_N.
DR PANTHER; PTHR13383; RIBONUCLEASE H2 SUBUNIT B; 1.
DR PANTHER; PTHR13383:SF11; RIBONUCLEASE H2 SUBUNIT B; 1.
DR Pfam; PF09468; RNase_H2-Ydr279; 1.
DR Pfam; PF17745; Ydr279_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 27..109
FT /note="Rnh202 triple barrel"
FT /evidence="ECO:0000259|Pfam:PF17745"
FT DOMAIN 112..313
FT /note="Ribonuclease H2 subunit B wHTH"
FT /evidence="ECO:0000259|Pfam:PF09468"
FT REGION 252..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 45847 MW; 7F538C19B38202BA CRC64;
MPTEETKTSN PKRKIPQSVD VPTKTFILPS KRSDAARFLS LPNPTSGVLN RYFFDPEETG
LYEFTAVAST QFAPRSILFT SNNSNEKTEE RAKGYLAKKA ELFIATPIDV LFFMLPIVAP
ADKTSTSNMF QPLDDILDSQ DELSAHLRYI VYNASFRSTI ERRMQAICDT MEAADEKLYR
FSETKLLAEL ITKAARMIAQ GLPASLEQNF IQKTLAPPLM SVKREDTVTT TATIIEHEEN
QDLEVVEMQS TSTTTISTTL SAEPSGVSTP ATQPSTVDEI SPSSGSVARL LRLRIALSFI
KQSYLPPNLS TRIEEILKSP ESPIDFKPLD DRLKELADLR AEAFASRAME DLSRKRGFEE
EDGDSERAAA KRKKEEEKKA KAAESRGVRE LKKVNTSGMK KMSDFFKKKS
//
