ID B8MB38_TALSN Unreviewed; 852 AA.
AC B8MB38;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=DUF221 domain protein, putative {ECO:0000313|EMBL:EED18739.1};
GN ORFNames=TSTA_124600 {ECO:0000313|EMBL:EED18739.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED18739.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; EQ962655; EED18739.1; -; Genomic_DNA.
DR RefSeq; XP_002482731.1; XM_002482686.1.
DR AlphaFoldDB; B8MB38; -.
DR GeneID; 8098411; -.
DR VEuPathDB; FungiDB:TSTA_124600; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_0_0_1; -.
DR InParanoid; B8MB38; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 366603at2759; -.
DR PhylomeDB; B8MB38; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 39..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..208
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 228..433
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 444..722
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 310..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 96590 MW; 7FF0F1E0979F8140 CRC64;
MSSTGGISTP VQFAAIASST VPGDHPIDWG SQAQGGRDLA TQLILSATLG LSAFFSFCIL
RPKWTELYAA RRKRRNAASF LPELPDSFFG WMPVIYRITD EEVLESAGLD AYVLLSFFKF
AIKFLSATFA FATLIIMPLH LRYAGQWGVP GWDHDDDDND DDGQSLFARD ILFGHGNKKF
KSDPTYLWIY VIFPYVFTGI AIYLLIHETN KIIRVRQNYL GSQTSTTDRT FRLSGIPTEL
RSEEKIQEII EDLHIGKVEA VTLCRQWHDL DLLMEERKKI LKPLERAWTK YLGYKQKRRY
NDTLPLVRAS RDRSPSLESE TATEHSQLLG SEDGRVPVRT VHKRRPTTRL WYGPFKLRYK
NVDSIDYYEE KLRRIDERIL AARQKEYPAT DLAFVTMETI SACQLVVQTI IDPHPTQLVP
SLAPAPADVV WKNTYIPRSS RISRSWLITL VISFLTIFWS VLLVPIASLL DLNTLHKAIP
GLADLLARHP IIKSLVQSSL PTITLSLLTV AVPYLYSWLS SLQGMTSRGD LELSIISKNF
FFTFFNLFFL FTVLGSASNF YGFLQNVQNA FKDATTIAFA LATSLENLSR FYINLIILQG
LGLFPFRLLE FGSVAMYPIN VLYAKSPREY AELSAPPKFS YGFTIPQTIF IFIICVVYSV
FPSSWLVCFC GLIYFFLGHF IYKYQLLYAM DHQQHSTGRA WPMICSRVFL GLVVFQVAMI
GVLALRKLIA RSLLLVPLLG ATVWFTYFFA KTYEPLMKFI ALRSIDHDRP NRSNGNNSDD
SLSPPPLLSP LSGLDRDALP ILIGGREIGL RLRKYVNPNL TIPLDGAWIP RSDGSIVIRP
SAVEEEHIAG EA
//
