ID B8MGE5_TALSN Unreviewed; 419 AA.
AC B8MGE5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN ORFNames=TSTA_013650 {ECO:0000313|EMBL:EED16265.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED16265.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR EMBL; EQ962656; EED16265.1; -; Genomic_DNA.
DR RefSeq; XP_002483499.1; XM_002483454.1.
DR AlphaFoldDB; B8MGE5; -.
DR STRING; 441959.B8MGE5; -.
DR GeneID; 8099164; -.
DR VEuPathDB; FungiDB:TSTA_013650; -.
DR eggNOG; KOG2361; Eukaryota.
DR HOGENOM; CLU_029724_1_1_1; -.
DR InParanoid; B8MGE5; -.
DR OMA; PAKYWDI; -.
DR OrthoDB; 5471626at2759; -.
DR PhylomeDB; B8MGE5; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809:SF11; METHYLTRANSFERASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transferase {ECO:0000256|PIRNR:PIRNR037755}.
FT DOMAIN 139..251
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
FT REGION 300..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 48305 MW; CAE8D78AB1105816 CRC64;
MPALPPDGDY VTISQLVEPP TIPSWRSHDP ARNAKRTDPF AFGQRYLEEG DDVFSYNAWD
HVETDEDYKA YAELQYAKQR ENPASDWHKA LYNSNPAKFW DRFYKNHNQN FFKDRKWLRQ
EFPVLAEVTK QGAGRKVVLE VGAGAGNTAF PLINNNENEE LMLFACDYSK NAVKVMRESE
HYNEKFMRAE VWDVTQEEEE IDGEIKSSLP PGVEEGSVDV VILIFIMSAL APNQWSAALR
NIYRVLKPGG LVLFRDYGRG DLAQVRFRKE RYLAENFYVR GDEELRKIWS TWTSEKGLTM
VHSGNDSDSS DRYDKTENLE GNQTEDNPER TSDETADKQR EQKLIERTDK TGESVEGAFE
VLNLGKDQRL LVNRQRRLKM YRCWLQARFR KRVVDNSGES QQLAPTAESI AEGLAATTL
//
