ID B8ML75_TALSN Unreviewed; 477 AA.
AC B8ML75;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Monocarboxylate permease, putative {ECO:0000313|EMBL:EED14990.1};
GN ORFNames=TSTA_044560 {ECO:0000313|EMBL:EED14990.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED14990.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family.
CC {ECO:0000256|ARBA:ARBA00006727}.
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DR EMBL; EQ962657; EED14990.1; -; Genomic_DNA.
DR RefSeq; XP_002484943.1; XM_002484898.1.
DR AlphaFoldDB; B8ML75; -.
DR GeneID; 8104132; -.
DR VEuPathDB; FungiDB:TSTA_044560; -.
DR eggNOG; KOG2504; Eukaryota.
DR HOGENOM; CLU_001265_1_0_1; -.
DR InParanoid; B8ML75; -.
DR OMA; YGRYNIF; -.
DR OrthoDB; 2607959at2759; -.
DR PhylomeDB; B8ML75; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17352; MFS_MCT_SLC16; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360:SF224; MFS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11360; MONOCARBOXYLATE TRANSPORTER; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..469
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 51408 MW; 435593280AC7236D CRC64;
MKWVSSENLH PEGDGTPGNG GILSSGTSAS TLHLPEAPVS DEKINSIQDV QASSSTTHST
TDLPEVLSTN EKIDSVPDGG LPAWLVVLGA WCGLFCSLGW LNSIGIFQSY YETTLLHQYS
ASAISWIPSF EIFFTFVMSP IIGQLYDRFG PRFVILGGSF LHVFGLMMAS LSTSYYQLLL
SQGVCSALGI CAIFQPCMSC IPSWFQRKRG IAYGIISSGT SLGGVIFPIM VSRLIKVVGY
AWSMRISAFL ILFLLVIVNL TVKTRLPPSS QTHKMSKKTL LQPLKEITMI LVVLGFFFLT
FGVFVPINYL VVQATKVGMS SNLAQYLAPI LNAASLFGRL LAGVLSDRVG TYNVLMIACY
LAGIFCLALW IPAANTAAVM AFTILFGMTS GAYIALAAAL VVRISPIREI GYRTGLLFFI
GAFSGLTASP IAGAILQRED GSYTGMQVFS GATLLVGSSF ILVVRIYKTG PVLRARF
//
