ID B8MLU3_TALSN Unreviewed; 561 AA.
AC B8MLU3;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Pre-rRNA-processing protein IPI3 {ECO:0000256|RuleBase:RU369067};
GN ORFNames=TSTA_101090 {ECO:0000313|EMBL:EED13869.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED13869.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000256|ARBA:ARBA00002355,
CC ECO:0000256|RuleBase:RU369067}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000256|RuleBase:RU369067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369067}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family.
CC {ECO:0000256|ARBA:ARBA00010143, ECO:0000256|RuleBase:RU369067}.
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DR EMBL; EQ962658; EED13869.1; -; Genomic_DNA.
DR RefSeq; XP_002486107.1; XM_002486062.1.
DR AlphaFoldDB; B8MLU3; -.
DR STRING; 441959.B8MLU3; -.
DR GeneID; 8101797; -.
DR VEuPathDB; FungiDB:TSTA_101090; -.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_025946_1_0_1; -.
DR InParanoid; B8MLU3; -.
DR OMA; VQSVDFY; -.
DR OrthoDB; 21962at2759; -.
DR PhylomeDB; B8MLU3; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0097344; C:Rix1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763:SF0; WD REPEAT-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR18763; WD-REPEAT PROTEIN 18; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|RuleBase:RU369067};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|RuleBase:RU369067};
KW Signal {ECO:0000256|SAM:SignalP};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..561
FT /note="Pre-rRNA-processing protein IPI3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002877672"
FT REPEAT 126..159
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 185..229
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT COILED 451..516
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 561 AA; 60821 MW; 82A71FC11C1D51DC CRC64;
MLSVTLIASL LGSSKTQTSS TLRDAGICVQ DLLPTSALRA TFKKSSTPPN GLAVTSTHIF
AAQIDKSVVH VYSRLKGNQE ATVPFPERIR SLAVAGGHNG EILILGTEGG RLILWETCTG
RQVSTTPSHL RPVTSLVVDP TSNIILSGSA DANVHIWSIP QLLSFSRPVS TGQDQKALNS
PIRTFGNHRT PITALAIGHG SGRSNIAISA AQDSTAVVWE YATGKVLRTF LLPSVAISIT
VDPADRACYV GYESGNVQRI GFYETMSAQH PLYDQRLQNT PSQLNDDQQW TVPSADKGAT
TALALSYDGM TLYSGHPNGS VLSWDIARGK FSTTIADYMS PVTNLHMLPP VGFPAKSNHD
SSRFTIPTIV KPRYEQNIPD KSLGDGIIPF NYALNVQLVS PASKTDVFSE ALTHPVFPTS
LLEEGLAELA ALNDNQDVLE VTISNGHSTA AAVESSQLAA MEEEITTLKK QLSINEAARR
ADAEETVKLK TSIRELQDSN KRYQHLQAKY EQLKVVALAE KEDRDLEQRK AWFESEKAGV
NGDGVLREAR AAYRDLDEMG E
//
