ID B8MMN1_TALSN Unreviewed; 2110 AA.
AC B8MMN1;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Nonribosomal peptide synthase SidD {ECO:0000313|EMBL:EED13785.1};
DE EC=5.1.1.11 {ECO:0000313|EMBL:EED13785.1};
GN ORFNames=TSTA_100300 {ECO:0000313|EMBL:EED13785.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED13785.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; EQ962658; EED13785.1; -; Genomic_DNA.
DR RefSeq; XP_002486023.1; XM_002485978.1.
DR STRING; 441959.B8MMN1; -.
DR GeneID; 8097914; -.
DR VEuPathDB; FungiDB:TSTA_100300; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_2_1; -.
DR InParanoid; B8MMN1; -.
DR OMA; IQYTMLY; -.
DR OrthoDB; 3305653at2759; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0047462; F:phenylalanine racemase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EED13785.1};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 774..850
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1577..1653
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2110 AA; 234767 MW; 206F9AB0D86438F3 CRC64;
MGSVQDVHLS PGPDGQHSKQ AKDSVMELET ENEPKGFRSF KLDNLAAKEN LSPTGMRDGL
VLLSWCMVLL RTSEDGQVSF EWAYRGKSKN LNVQSLSTAE VIPTLKCRLE KAASGIVRVI
NIKSWDQNTL ASGPASLVLS TNLLTETNSE VDFEKETLHL ELHFINGSLE ISPIWSTANV
SPFTVTRYIN ALIDTIKICI SKPNSPIEDC IGPTAHDLDE IWRWNHQLPP SYQFCMQDLI
SKRARTTPDK VAIDSWDGSL TYGQIDRYSS FLAKILKDMS GQLHEFIPLC FEKSRWTIVA
VLAVMKAGRT FVMMDPTIPL ARLRNMREQV GAKTMLSSRK QHRLSTSIIS EGKPLVVEED
TFVQVTNQEA VPELPPVSSD TLMYIIFTSG STGTPKGVKI SHETYTSSAI PRAKAVGYTE
DSRVLDFASY AFDVSIDSML LTLANGGCLC IPSDEDRMND INGVIRKMRV NYAGITPSVA
RILESDVIAS LSGLGLGGEA ASARDVMIWG QETRIIIGYG PCECTIGCTV NSSAATGRDY
ISIGTGNGAA IWIVDPNNHE KLMPVGAVGE LLIEGPIVGQ GYLNDPEKTA AAFIEGPKWL
LVGHGNYAGR RGRLYKTGDL GKYDPDGSGG IVFAGRKDTQ VKLRGQRVEL GEIESQLKAR
LPLNTNVIAE VIVPQRPGNQ ATLVAFVSQS TKASGAAADI SSVSLSNEMQ TALSQANTEL
TKVLPRYMVP TAYIPVNYIP VLISGKTDRR RLRQFGATIE LRNLDQNKED KPERELNDFE
QRLRQAWGQI LKVDAETIRL EDNFFVLGGD SLAAMRLVSV CREQELDLTV ANTFDYPTLA
AMTSVIRVHN SQTRVEAQPF SMLSHDANSL YLEANELYGF DRASIEDIYP CTPTQESLFT
FSLKSVEPYI AQRVACIPPS ISLESWKKAW EAVVAASPIL RTRLAQLQER GLLQLVLKQG
ISWNYSTDLD QYLSHDKEHR MDLGQPLARY TIIDDSKDGK RYMVWTIHHV LYDGWSEPIA
LQKVSDALKG QDVKFRTQIR EFIKYVRDTD EVAMQEYWRS ELKDAVGPQF PQLPSRDYVP
TPDAMVEHYI PIDTRSKGSQ FTMATLIRGT WALVASQYTR SDDIVFGETL TGRDIALAGV
EEIVGPLIAT VPVRVYVHRA SSVEVYLQTI QQSMRGRTRY QHMGMQNIRK VSRDAQHACE
ASTGLVIQPE PEYTGDELGF VQGDVVHEAL HFNPYPLMIA CGIRKDGFRV CANFDSSLID
VSQMKRILKQ FEVAYAQLAI NTSRKLGDIS CLPEAELDQI WHWNQVPPCS FDISAGQLRA
GVSIRQGSAY PPPMVPWVCD PRNPSLLSPI GCMGELWLEG DVLSENIIES PAWLIAGSSG
INGRSGRVHP TGDIVQLQED GSLIYVGRKE NTVVSQGHAV NISDLEAYLS RYLPSEIRAA
AVTFIPSMES SSQPVEQELV VFIEQQPNSW EDSVELMWMQ HRVNCEVSGS DIFEATICNT
VTNSLAAALQ KFNKFAQDSL SSYMTPTAYI IVEQLPSTMG RIDHELLRKL GSNIPSHVFT
QVREGFTNVW AKSLSQTQLT ACEEILRSSW ANILGTPPEK IDVDDNFFRL GGDSVLAMKL
VSNIRARGHS LTVADIFQHM RLGDAAKVLK VNHDLKREET QAYKPFSTLV NVDTEKFLSD
IVRPKLKNSQ WSIQDITPVT DSQALDIRGT VQAPRTSVQY TMLYFKNDID LERLLDACNN
LVKTHDILRT VFVEHHCSYF QVILDNLTTT IETCKTDLEL EKHIASLCTE DIESQFELGC
PFFKWLHVEG PAGQHCLVIR LSHAQYDGIS LPRMFRDLEK LYIGDKITGF KPFPAYVACI
LDGNAQDKAI DYWKNVLNES SLSVLQGKSQ LPVTKSIFRT KIVETVSLPL EDITTASLLT
AAWALVLARH LKITDITFGG VTSGRVNDLE NVENVVGPCY QFTPIRIRFE RQWTGMDLLK
FVQKQNSESA AHDFLGFEKI SKTCTQWASA SPERRLFFDS VVHHQDFEDF DTMPFAGGNC
KVDILSPHGD SADPLKVVSF VQEGKLHVGI VGSEHDLEFV DTLLKELAKA AEELVVRGSA
HIFLDSSSAC
//
