ID B8MUK6_TALSN Unreviewed; 1977 AA.
AC B8MUK6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Reverse transcriptase, putative {ECO:0000313|EMBL:EED11674.1};
GN ORFNames=TSTA_108600 {ECO:0000313|EMBL:EED11674.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED11674.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
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DR EMBL; EQ962661; EED11674.1; -; Genomic_DNA.
DR RefSeq; XP_002488430.1; XM_002488385.1.
DR GeneID; 8103116; -.
DR VEuPathDB; FungiDB:TSTA_108600; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_233969_0_0_1; -.
DR InParanoid; B8MUK6; -.
DR OrthoDB; 2169222at2759; -.
DR PhylomeDB; B8MUK6; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EED11674.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:EED11674.1};
KW Transferase {ECO:0000313|EMBL:EED11674.1}.
FT DOMAIN 1151..1431
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1643..1780
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1762..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1977 AA; 218990 MW; 9AFC99FA5B894EE0 CRC64;
MESPERPPGA TGDPEIMGPG SGVDSSTPSQ EPSQLPPTTR ALFAGLGDCQ KQSNEPTLSN
SDALQAPRQT GETQQAPGTI LEKRKASRLT IGSRTPITRS GLSAAPKRKI TLTAMRAASA
TAEDSLVMGL IEDLNGHLQE AVHQLSAELT TARNVINTQQ GLITTLNARL ESLETYVNAL
QSRQILPLDP FAATREVAAH GPPPRAASTG GLASTPIQLD AAPESRAINS TAPQPQPRYQ
NPTKATKQAI QPPEGPKKPA PTKWAAIAAN NTQSGGWKTV QYKKQALAPS KALSTTNLKP
VSTRSKEERR LIFRRRYPKD APTALKADIL LALNRALAKA GLPDFVRAVD SGYAASGALT
VLLERGTRSS TLVPVHNDTL LAAVRQTDPA VISVEISEQW HRVKVQAVPV DRYMYNDQGL
ALAQEEIELG TPYRLKREPT WLKRAKTIQA SNQRFATIVM TVGSLEEART LINKGIKFGG
RHHRVAPYWE SNPESICPRC CGIGHSGFMA CGGKPPKCAI CAGDHEAIEH SCTVVDCRVG
PAKPCKHTVI RCANCKGAHE ATSPKCPKAR EARQRAIRRM REQSLQDLIP LDETFAVVPP
KPVLTSEERP GQSLEEETST PEEDELLPEM QLEADIHEGN SQQPLEPELK SATEAPQSAV
VHTALEVALQ AGAGIACLQE PPVRGKYQIS HPGFLFYWPE GPREHARVVT AIRRDLVREL
VVEARTDLAN HPYFMVVDVL EQGRRTRIVN CYDNWLGARH TYSGESLLTR RALTDLDWGP
ILEGRCLILG DFNAHSPMWN VHIDQRVNAR SLEDLIMRHD LFINNDPDEP TRPHKPRDST
ASFETSTETR VSIIDLTISS QALGPLSGWE IESQRLTPSD HVMIWASWEP PATTSTEPTR
KEVTGWQIEA LLGDKKALQE AKDTWNELAK TQPILTDTTL TEEVEREAEW IERTLTEVLN
KHCKQIRLCA RSKRWWNSEI EAERSVYSKA RKAYQAGEIS DEEHREARKS FYSLIRRAKR
ECWEGFLQGT SEGSLPDQKR CWTALRYTKP QTQGTTPALT DEASGEVIAA TFSEKEEVFR
HRAFPQAPNS NMELQLPERG SAHKLVNEEV VKNALFSQGL EKAPGTDLLN FRAIRLLWNL
DSERVVSLTR QCLRLGIHPR VWKTAKGVLL RKNGKTNYTL ASAYRVISLL KCLGKVIEKL
VAELITNFAE AQDLFHDGQF GGRRQRSAID AVACLVEEIH QAWANRKLAA ALFMDIEGAF
DHVILAKLVE VLREASVDGD LIHWVISFLS DRRVTLVIDG HVGKEVPISS GLPQGSPVSP
ILFVLYVHGL SRAIERSVPE VRCLSFVDDQ GLVTAASSVK EACRILEKAA EVAIEWGVAN
GVQFDRKKTE AAFFYRRHRR QVAQNVSRAR IRVGGELATV KSTVRWLGIL LDNQLTWKSH
YNARIKTARN TIIRLNSLCR ANGLPPALVR RIQKATVQAQ LLWGAEIWWQ GQKTWAQRIQ
ILINKQARGI TGMFPKTPIG ALIREAALEP ATVLLDARVA RYTARLLALP DTHPTAQILP
VTLRHGDLHA QPGEQPLDDR EWASRDNKVL NRLGQRLAKH LAQRLNRDPS GGIERTEQYE
LKSFPGSIRV LDKEEALTEA NQQRAGTTFW SDGSRLDTGR AGAGVTLQAV PGGPWEHVEV
PMGHGHEVFD AELVGVATAL EWALERQPLG PIWVLLDAQN AIDRLRSTRP GPGQALVLRA
HKAAEKLALR GQPVTIQWVP GHSGIEGNEQ ADQAAKRAAS KQTAPGFEDL SLAHVRRACT
EARRAAVSEW ARINAVQGRH RDGRVYKMPR GWNLDPVAGK APKRLASRYY QLKTGHAPIG
TYLHRIGRRE SPECQACKEP HETVRHVLFE CRGRRTGRRA LYRALEKAGV PLPTAAEESP
EARLFAEPRA TQGLLQFVAE ANLFNDNERT AREAEISDVW GWDTLEEGGL GVTLEDG
//
