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Database: UniProt
Entry: B8N3B7_ASPFN
LinkDB: B8N3B7_ASPFN
Original site: B8N3B7_ASPFN 
ID   B8N3B7_ASPFN            Unreviewed;       857 AA.
AC   B8N3B7;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   05-JUL-2017, entry version 46.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=AFLA_027300 {ECO:0000313|EMBL:EED55458.1};
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM
OS   12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=332952 {ECO:0000313|EMBL:EED55458.1, ECO:0000313|Proteomes:UP000001875};
RN   [1] {ECO:0000313|EMBL:EED55458.1, ECO:0000313|Proteomes:UP000001875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
RC   {ECO:0000313|Proteomes:UP000001875};
RX   PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; EQ963473; EED55458.1; -; Genomic_DNA.
DR   RefSeq; XP_002374240.1; XM_002374199.1.
DR   ProteinModelPortal; B8N3B7; -.
DR   STRING; 5059.CADAFLAP00002105; -.
DR   PRIDE; B8N3B7; -.
DR   EnsemblFungi; EED55458; EED55458; AFLA_027300.
DR   GeneID; 7917820; -.
DR   KEGG; afv:AFLA_027300; -.
DR   EuPathDB; FungiDB:AFLA_027300; -.
DR   HOGENOM; HOG000037059; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001875};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001875};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    550    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    580    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    646    666       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    783       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    789    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   857 AA;  97686 MW;  0DBD0FF2A876FA15 CRC64;
     MAPKDTFFRS SDMSLTQLYI ANEIGREVVS ALGELGQVQF RDLNPDTNAF QRTFTKEIRR
     LDNVERQLRY FHSQMDKAGI PMRSSSEFTD TLAAPLASEI DELAERSESL EQRIASLNDS
     YETLKKREVE LTEWRWVLRE AGGFFDRAHT HTEEIRQSFD NDEAPLLRDV EQQSHRGQNG
     EAQGQQSFLE MNIGFVAGVI PRDRIGAFER ILWRTLRGNL YMNQSEIPEA IIDPTTNEES
     HKNVFVIFAH GKNIIAKIRK ISESLGASLY GVDENSELRR DQIHEVNTRL SDVGNVLRNT
     KNTLDAELTQ IARSLAAWMI IVRKEKAVYD TLNRFSYDQA RKTLIAEAWC PTNSLPLIKS
     TLQDVNDRAG LSVPTIVNQI RTNKTPPTYV RTNKFTEAFQ TIVNAYGIPK YSEANPGLYT
     IVTFPFLFAV MFGDFGHGAL MTLCAAAMIF WERKLQKTKL DELTYMAFYG RYIMLMMGLF
     SMYTGLIYND IFSKSFTIFS SQWKWPEIIH PGQAVEASLK GDYRFPFGLD WNWHEAENSL
     LFTNSLKMKM SILLGWSHMT YALCLQYVNA RHFKSKVDII GNFLPGMIFF QSIFGYLVLT
     VIYKWSVDWP ARGQSPPGLL NMLIFMFLSP GSVEEELYPG QGSVQVILLL LAVAQVPVML
     LFKPLYLRWE HNRARAHGYR GLGEQSRVSA LEDDGDMDGG LNGGRGSMAS EGEGVAMIAQ
     DLGEEEHEEF DFSEIMIHQV IHTIEFCLNC ISHTASYLRL WALSLAHQQL SIVLWTMTLG
     GAFEQENPTL RVIMIVVTFY LWFTLTIAIL CVMEGTSAML HSLRLHWVEA MSKHFMGEGI
     PFAPFSFKAL LEEDPVD
//
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