ID B8NA44_ASPFN Unreviewed; 1146 AA.
AC B8NA44;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Ras guanine-nucleotide exchange protein, putative {ECO:0000313|EMBL:EED53963.1};
GN ORFNames=AFLA_113400 {ECO:0000313|EMBL:EED53963.1}, G4B84_005008
GN {ECO:0000313|EMBL:QMW29673.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED53963.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED53963.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED53963.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW29673.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW29673.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EQ963475; EED53963.1; -; Genomic_DNA.
DR EMBL; CP059868; QMW29673.1; -; Genomic_DNA.
DR RefSeq; XP_002377209.1; XM_002377168.1.
DR AlphaFoldDB; B8NA44; -.
DR STRING; 332952.B8NA44; -.
DR EnsemblFungi; EED53963; EED53963; AFLA_113400.
DR VEuPathDB; FungiDB:AFLA_007289; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_1_0_1; -.
DR OMA; EEVWERD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 3.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 57..123
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 677..797
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 857..1100
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 32..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 127729 MW; 54332F3DE8828D04 CRC64;
MEPMKPHIAP LKIEKGNSNF YSNRFYCTQH HQMTPPLTPS NTKKDDSMEE TETPRAVFHN
YLRAFYPFHP SGDVSPATIT LPLDQGDIIL VHSVHTNGWA DGTLLDTGAR GWLPTNYCEA
YDQLPMRPLL KALTDFWDII QGGCGFPLRE FCNQDTVKGL IAGVRFLLEK SECLTRDSVL
VRSHDGLRRN RKALLADLSS LVRTTKRCQE MPSSTNDTEH EVCMMDEMLL KAFRIVTRGV
RFLDIWTEEV GLSRTIAELG QATHFDILPT PMSETFPSEA DTERGESRLL NRSRLDMSRA
SNRTDTIESQ SHRPVSVSTK RISHRVSCSA PAAASRNPNL ASERLNTTYD AFLGVLGSFI
GLHLQSRPST ELVVTTEQAV RSCRGLLTVV EAVCEHDPQG CGLLEQARDT MYDRLSELVY
AARDAFRPAH SADDELIFMP DEGKRLVDAA TDCVRGAGNC LAKARWMLEQ SGDFELEALT
QDSSTVHDIQ TTPIPQRTGS LAGDQKEVSL RLPPPPLEIP VKKNLRDSTS TPGLTEAATP
SSFNSRALVT PTTDNTDQPT AMLSTSLDKM STSLMQDAHV ADSIQCRDSH PTSEVSESFG
RGITSTGSSF TYNSHLRDSE MSGVSQTSTR ATSPDICNSY QAPSLHGSIS HSTLAEENEE
TEANILEKTF AHELIFKDGQ VMGGSLRALV EKLTAHGSTP DAMFVSAFYL TFRLFATPME
FAETLVDRFI YIGDTPHAAG PVRLRVYNVF KGWLESHWRH DCDNVALDFI MNFANTTLMQ
NLPSAGKRLA ELAEKVSAVH GPVVPRLVSS MGKTNTATAQ YVHPDAPLPP PILGKKENNL
LRQWKHGEGS LSILDFDPME LARQFTIKES RIFCSILPEE LLATEWMKKS ASLAVNVRAM
STLSTDLAHL VADSILQLEE PKKRAATIKH WVKIANKCLE LDNYDTLMAI ICSLNSSMIS
RLKRTWEIVS QKTKTTLESL RGIVDVSRNY AVLRQRLQNR IPPCLPFVGT YLTDLTFVDH
GNQPLRSLPT EDGEMAVINF DKHMKTAKII SELQRFQIPY RLTEVPELQA WMQNELIRVR
SSGEKSMQTF YRRSLVLEPR DPPQTPRSIP PQPESSASSI LENAKDKFDF LSWTHPSKAK
SVATNG
//
