ID B8NCS4_ASPFN Unreviewed; 497 AA.
AC B8NCS4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Peroxisomal multifunctional beta-oxidation protein (MFP), putative {ECO:0000313|EMBL:EED52457.1};
GN ORFNames=AFLA_041590 {ECO:0000313|EMBL:EED52457.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED52457.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED52457.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|RuleBase:RU000363}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ963476; EED52457.1; -; Genomic_DNA.
DR RefSeq; XP_002377621.1; XM_002377580.1.
DR AlphaFoldDB; B8NCS4; -.
DR STRING; 332952.B8NCS4; -.
DR EnsemblFungi; EED52457; EED52457; AFLA_041590.
DR VEuPathDB; FungiDB:AFLA_007723; -.
DR eggNOG; ENOG502QPX4; Eukaryota.
DR HOGENOM; CLU_010194_18_4_1; -.
DR OMA; HYLEIHR; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 372..483
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
SQ SEQUENCE 497 AA; 54160 MW; 2B230E970523BC86 CRC64;
MNDDLWNPVL NVHLRGTYKV TKAAWPYMLK QKYGRIVNTA STSGIYGNFG QANYAAAKLG
ILGFSRTLAI EGAKYNIKVN TIAPNAGTNM TRTIMPEEMV QAFKPDYVAP LVVLLSSDIV
PGTGTKGLYE CGSGWFTSTR WQRSGGHGFP VDVKLTPEEV VKNWKKITNF DDGRADHPED
SQAGSEKVMA NMGNRSDAAE GGNDILANIE KAKQATTDGT AFDYADRDVI LYNLSLGAKR
TDLPFVYENN EHFQALPTFG VVPWFNTTVP YNMDDIVKNF SPMMLLHGEQ YMEIRKFPIP
TEAKTLTFPK LIDVVDKGAA ALVVAGFTTK DAKTGEDLFY NESTVFIRGS GGFGGSPKPT
AARPKGATAA YKAPQRKPDA VVEEKTSEDQ AALYRLNGDR NPLHIDPEFS KVGGFKTPIL
HGLCSLGVSG KHVYSKFGAY KNIKVRFAGV VLPGQTLRTE MWKEGNTVLF QTTVVETGKP
AISGAGVELL EGAKAKL
//