ID LIS12_POSPM Reviewed; 427 AA.
AC B8PD53;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-APR-2013, entry version 29.
DE RecName: Full=Nuclear distribution protein PAC1-2;
DE AltName: Full=Lissencephaly-1 homolog 2;
DE Short=LIS-1 2;
DE AltName: Full=nudF homolog 2;
GN Name=PAC1-2; Synonyms=LIS1-2; ORFNames=POSPLDRAFT_89201;
OS Postia placenta (strain ATCC 44394 / Madison 698-R) (Brown rot fungus)
OS (Poria monticola).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC Agaricomycetes; Polyporales; Postia.
OX NCBI_TaxID=561896;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44394 / Madison 698-R;
RX PubMed=19193860; DOI=10.1073/pnas.0809575106;
RA Martinez D., Challacombe J., Morgenstern I., Hibbett D., Schmoll M.,
RA Kubicek C.P., Ferreira P., Ruiz-Duenas F.J., Martinez A.T.,
RA Kersten P., Hammel K.E., Vanden Wymelenberg A., Gaskell J.,
RA Lindquist E., Sabat G., Splinter BonDurant S., Larrondo L.F.,
RA Canessa P., Vicuna R., Yadav J., Doddapaneni H., Subramanian V.,
RA Pisabarro A.G., Lavin J.L., Oguiza J.A., Master E., Henrissat B.,
RA Coutinho P.M., Harris P., Magnuson J.K., Baker S.E., Bruno K.,
RA Kenealy W., Hoegger P.J., Kuees U., Ramaiya P., Lucas S., Salamov A.,
RA Shapiro H., Tu H., Chee C.L., Misra M., Xie G., Teter S., Yaver D.,
RA James T., Mokrejs M., Pospisek M., Grigoriev I.V., Brettin T.,
RA Rokhsar D., Berka R., Cullen D.;
RT "Genome, transcriptome, and secretome analysis of wood decay fungus
RT Postia placenta supports unique mechanisms of lignocellulose
RT conversion.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:1954-1959(2009).
CC -!- FUNCTION: Positively regulates the activity of the minus-end
CC directed microtubule motor protein dynein. May enhance dynein-
CC mediated microtubule sliding by targeting dynein to the
CC microtubule plus end. Required for nuclear migration during
CC vegetative growth as well as development. Required for retrograde
CC early endosome (EE) transport from the hyphal tip. Required for
CC localization of dynein to the mitotic spindle poles. Recruits
CC additional proteins to the dynein complex at SPBs (By similarity).
CC -!- SUBUNIT: Self-associates (By similarity). Interacts with NDL1 and
CC dynein (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
CC Cytoplasm, cytoskeleton, spindle pole (By similarity).
CC Note=Localizes to the plus ends of microtubules at the hyphal tip
CC and the mitotic spindle poles (By similarity).
CC -!- DOMAIN: Dimerization mediated by the LisH domain may be required
CC to activate dynein (By similarity).
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC -!- SIMILARITY: Contains 1 LisH domain.
CC -!- SIMILARITY: Contains 7 WD repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; EQ966319; EED81189.1; -; Genomic_DNA.
DR RefSeq; XP_002473604.1; XM_002473559.1.
DR ProteinModelPortal; B8PD53; -.
DR STRING; 104341.JGI89201; -.
DR GeneID; 8140021; -.
DR KEGG; ppl:POSPLDRAFT_89201; -.
DR eggNOG; COG2319; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1; -.
DR InterPro; IPR017252; Dynein_regulator.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH_dimerisation.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR PANTHER; PTHR22847:SF51; PTHR22847:SF51; 1.
DR Pfam; PF00400; WD40; 7.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40_like; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm;
KW Cytoskeleton; Microtubule; Mitosis; Repeat; Transport; WD repeat.
FT CHAIN 1 427 Nuclear distribution protein PAC1-2.
FT /FTId=PRO_0000405099.
FT DOMAIN 8 40 LisH.
FT REPEAT 106 147 WD 1.
FT REPEAT 149 187 WD 2.
FT REPEAT 194 233 WD 3.
FT REPEAT 236 275 WD 4.
FT REPEAT 278 336 WD 5.
FT REPEAT 339 378 WD 6.
FT REPEAT 381 420 WD 7.
FT COILED 58 82 Potential.
SQ SEQUENCE 427 AA; 47542 MW; D7AFF35284418C2E CRC64;
MSILSERQKD DLNKSIAEYL YAQDLTEIAD SLCARLSLDY KSEPNSKYAG LLEKKWVSVI
RLQKKLIESE NRYTALQEDI AAGPARRRDA QVDWLPTAPA RYTLTSHRAP ITRVAFHPTF
SLLASASEDT TVKIWDWETG SFERTLKGHT REVWGVDFDS KGSFLATCSS DLSIKVWDTQ
QWDNAGYSGK TLRGHEHTVS TVKFLPGDDL IASASRDKTI RIWEVATTFC IRTITGHEDW
VRMTVPSTDG TLLGSCSSDN TARVWDPTSG VMKMEFRGHG HIVEVIAFAP LASYAAIREL
AGLKAATKAP GAYIATGSRD KTVKIWDVHS GQELRTVSGH NDWIRGLVFH PSGKHLLSAS
DDKTIRVWEL STGRCMXVVE AHSHFITCLA WGPPVSAVAR VELPRTPFCG DPKPIASRIM
EEFNPRP
//
