ID B8QCH4_BOTAS Unreviewed; 190 AA.
AC B8QCH4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ACC85807.1};
DE Flags: Fragment;
GN Name=NGFB {ECO:0000313|EMBL:ACC85807.1};
OS Bothrops asper (Terciopelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=8722 {ECO:0000313|EMBL:ACC85807.1};
RN [1] {ECO:0000313|EMBL:ACC85807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18570036; DOI=10.1080/10635150802166053;
RA Wiens J.J., Kuczynski C.A., Smith S.A., Mulcahy D.G., Sites J.W.Jr.,
RA Townsend T.M., Reeder T.W.;
RT "Branch lengths, support, and congruence: testing the phylogenomic approach
RT with 20 nuclear loci in snakes.";
RL Syst. Biol. 57:420-431(2008).
CC -!- SUBUNIT: Homodimer; non-covalently linked.
CC {ECO:0000256|ARBA:ARBA00011804}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
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DR EMBL; EU437994; ACC85807.1; -; Genomic_DNA.
DR AlphaFoldDB; B8QCH4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR045815; NTF3_N.
DR InterPro; IPR020433; Venom_nerve_growth_factor.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR PRINTS; PR01917; VENOMNGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 117..190
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 33..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACC85807.1"
FT NON_TER 190
FT /evidence="ECO:0000313|EMBL:ACC85807.1"
SQ SEQUENCE 190 AA; 21420 MW; 4D0CBB060A9AB02E CRC64;
FLTGIWAAPK SEDNVPLGSP ATSDLSVTSC TKTHEALKTS RNTDQHYPAP KKEEDQEFGS
AANIIVDPKL FQKRRFQSPR VLFSTQPPPL SRDEQSVDNA NSLNRNIRAK REDHPVHNRG
EYSVCDSVNV WVANKTTATD IRGNLVTVMV DVNINNNVYK QYFFETKCRN PNPVPTGCRG
IDARHWNSYC
//
