ID B8X2D4_LISMN Unreviewed; 739 AA.
AC B8X2D4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Internalin A {ECO:0000313|EMBL:ACL37784.1};
DE Flags: Fragment;
GN Name=inlA {ECO:0000313|EMBL:ACL37784.1};
OS Listeria monocytogenes.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1639 {ECO:0000313|EMBL:ACL37784.1};
RN [1] {ECO:0000313|EMBL:ACL37784.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL_B-33330 {ECO:0000313|EMBL:ACL37784.1}, and NRRL_B-33425
RC {ECO:0000313|EMBL:ACL37840.1};
RX PubMed=18931295; DOI=10.1128/AEM.01127-08;
RA Ward T.J., Ducey T.F., Usgaard T., Dunn K.A., Bielawski J.P.;
RT "Multilocus genotyping assays for single nucleotide polymorphism-based
RT subtyping of Listeria monocytogenes isolates.";
RL Appl. Environ. Microbiol. 74:7629-7642(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the internalin family.
CC {ECO:0000256|ARBA:ARBA00009432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ024983; ACL37784.1; -; Genomic_DNA.
DR EMBL; FJ025011; ACL37840.1; -; Genomic_DNA.
DR AlphaFoldDB; B8X2D4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR012569; Inl_IR.
DR InterPro; IPR047600; InlA.
DR InterPro; IPR013378; InlB-like_B-rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR032675; LRR_dom_sf.
DR NCBIfam; NF033189; internalin_A; 1.
DR NCBIfam; TIGR02543; List_Bact_rpt; 3.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF09479; Flg_new; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF12799; LRR_4; 6.
DR Pfam; PF08191; LRR_adjacent; 1.
DR SMART; SM00365; LRR_SD22; 15.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51450; LRR; 13.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 715..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 706..739
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 647..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACL37784.1"
SQ SEQUENCE 739 AA; 79890 MW; 25414A52A83B2AC5 CRC64;
TVLGKTNVTD TVSQTDLDQV TTLQADRLGI KSIDGLEYLN NLTQINFSNN QLTDITPLKD
LTKLVDILMN NNQIADITPL ANLSNLTGLT LFNNQITDID PLKNLTNLNR LELSSNTISD
ISALSGLTNL QQLSFGNQVT DLKPLANLTT LERLDISSNK VSDISVLAKL TNLESLIATN
NQISDITPLG ILTNLDELSL NGNQLKDIGT LASLTNLTDL DLANNQISNL APLSGLTKLT
ELKLGANQIS NISPLAGLTA LTNLELNENQ LEDISPISNL KNLTYLTLYF NNISDISPVS
SLTKLQRLFF YNNKVSDVSS LANLTNINWL SAGHNQISDL TPLANLTRIT QLGLNDQEWT
NPPVNYKVNV SIPNTVKNVT GALIAPATIS DGGSYAEPDI TWNLPSYTNE VSYTFNQSVT
IGKGTTTFSG TVTQPLKAIF NAKFHVDGKE TTKEVEAGNL LTEPAKPVKE GYTFVGWFDA
QTGGTKWNFS TDKMPTNDID LYAQFSINSY TATFDNDGVT TSQTVDYQGL LQEPTAPTKE
GYTFKGWYDA KTGGDKWDFA TSKMPAKNIT LYAQYSANSY TATFDVDGKT TTQAVDYQGL
LKEPKTPTKA GYTFKGWYDE KTDGKKWDFA TDKMPANDIT LYAQFTKNPV APPTTGGNTP
PTTNNGGNTT PPSANIPGSN TSTGNSASTT STMNAYDPYN SKEASLPTTG DSDNALYLLI
GLLAVGTAVA LTKKARASK
//
