ID   FTHS_STRPJ              Reviewed;         556 AA.
AC   B8ZJQ0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   01-MAY-2013, entry version 28.
DE   RecName: Full=Formate--tetrahydrofolate ligase;
DE            EC=6.3.4.3;
DE   AltName: Full=Formyltetrahydrofolate synthetase;
DE            Short=FHS;
DE            Short=FTHFS;
GN   Name=fhs; OrderedLocusNames=SPN23F11250;
OS   Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=561276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700669 / Spain 23F-1;
RX   PubMed=19114491; DOI=10.1128/JB.01343-08;
RA   Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K.,
RA   Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J.,
RA   Bentley S.D., Mitchell T.J.;
RT   "Role of conjugative elements in the evolution of the multidrug-
RT   resistant pandemic clone Streptococcus pneumoniae Spain23F ST81.";
RL   J. Bacteriol. 191:1480-1489(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP +
CC       phosphate + 10-formyltetrahydrofolate.
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase
CC       family.
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DR   EMBL; FM211187; CAR68934.1; -; Genomic_DNA.
DR   RefSeq; YP_002511076.1; NC_011900.1.
DR   ProteinModelPortal; B8ZJQ0; -.
DR   SMR; B8ZJQ0; 4-554.
DR   STRING; 561276.SPN23F_11250; -.
DR   GeneID; 7328405; -.
DR   KEGG; sne:SPN23F_11250; -.
DR   PATRIC; 19673584; VBIStrPne132160_1195.
DR   eggNOG; COG2759; -.
DR   KO; K01938; -.
DR   OMA; EIMAVLC; -.
DR   ProtClustDB; PRK13505; -.
DR   UniPathway; UPA00193; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:HAMAP.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01543; FTHFS; 1; -.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   Pfam; PF01268; FTHFS; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   One-carbon metabolism.
FT   CHAIN         1    556       Formate--tetrahydrofolate ligase.
FT                                /FTId=PRO_1000185266.
FT   NP_BIND      65     72       ATP (By similarity).
SQ   SEQUENCE   556 AA;  59630 MW;  025035A325CF97FF CRC64;
     MKTDIEIAQS IELKPIVDVV EKLGISYDDL ELYGKYKAKL SFDKIRAVES NPVGKLILVT
     AINPTPAGEG KSTLTIGLAD ALNKIGKKTM IAIREPSLGP VMGIKGGAAG GGYAQVLPME
     DINLHFTGDM HAITTANNAL SALIDNHLHQ GNELGIDQRR ILWKRVVDLN DRALRHVTVG
     LGGPLNGIPR EDGFDITVAS EIMAILCLAT DIEDLKRRLA NIVIGYRYDR TPVSVGDLQV
     EGALALILKD AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALH LADYTVTEAG
     FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV EAVRAGFANL
     KRHVENIRKF GIPAVVAINE FVSDTEAEIA VLKELCASID VPVELASVWA DGAEGGVALA
     ETVVKTIAEN PANYKRLYDN DLSVQEKIEK IVTEIYRGSK VNFEKKSQTQ IAQIVQNGWD
     KLPICMAKTQ YSFSDNPNAL GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA
     ALNMDVESDG TVLGLF
//