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Database: UniProt
Entry: B8ZY39_SHEEP
LinkDB: B8ZY39_SHEEP
Original site: B8ZY39_SHEEP 
ID   B8ZY39_SHEEP            Unreviewed;       253 AA.
AC   B8ZY39; A0A6P3CXN8;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:CAX17685.1};
GN   Name=Ovar-DRA {ECO:0000313|EMBL:CAX17685.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|EMBL:CAX17685.1};
RN   [1] {ECO:0000313|EMBL:CAX17685.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ballingall K.T., Rocchi M.S., McKeever D.J., Wright F.;
RT   "Trans-species polymorphism and selection in the MHC class II DRA genes of
RT   domestic sheep.";
RL   PLoS ONE 5:e11402-e11402(2010).
RN   [2] {ECO:0000313|EMBL:AEP03656.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Qiu W., Dong H., Bai D., Gao J.;
RT   "Screening and Analysis of Structure of Genes in MHC 222G18 BAC Clone of
RT   Chinese Merino.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238}.
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DR   EMBL; JF735994; AEP03656.1; -; mRNA.
DR   EMBL; FM986336; CAX17685.1; -; mRNA.
DR   RefSeq; NP_001267646.1; NM_001280717.1.
DR   RefSeq; XP_011955819.1; XM_012100429.2.
DR   AlphaFoldDB; B8ZY39; -.
DR   SMR; B8ZY39; -.
DR   GeneID; 101109747; -.
DR   KEGG; oas:101109747; -.
DR   OrthoDB; 4118190at2759; -.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR   GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:Ensembl.
DR   GO; GO:0042608; F:T cell receptor binding; IEA:Ensembl.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002491; P:antigen processing and presentation of endogenous peptide antigen via MHC class II; IEA:Ensembl.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
DR   GO; GO:0050890; P:cognition; IEA:Ensembl.
DR   GO; GO:0002469; P:myeloid dendritic cell antigen processing and presentation; IEA:Ensembl.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IEA:Ensembl.
DR   GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0043382; P:positive regulation of memory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0045622; P:regulation of T-helper cell differentiation; IEA:Ensembl.
DR   CDD; cd05767; IgC1_MHC_II_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN-RELATED; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..253
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010108801"
FT   TRANSMEM        220..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          111..191
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   253 AA;  28462 MW;  96BFA681B44647A8 CRC64;
     MAITRVPILG LFITVLISLQ ESWAIKEDHV IIQAEFYLNP EESAEFMFDF DGDEIFHVDM
     QKKETVWRLP EFGRFASFEA QGALANMAVM KANLDIMIKR SNNTPNTNVP PEVTLLPNKP
     VELGEPNTLI CFTDKFSPPV ISVTWLRNGI PVTDGVSQTV FLPRDDHLFR KFHYLPFLPT
     TEDVYDCKVE HWGLNEPLLK HWEYEAPAPL PETTENAVCA LGLIVALVGI IAGTIFIIKG
     VRKANTVEGR GPL
//
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