ID B9A8E0_9VIRU Unreviewed; 1690 AA.
AC B9A8E0;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 08-NOV-2023, entry version 77.
DE SubName: Full=Non-structural polyprotein {ECO:0000313|EMBL:BAH22517.1};
OS Chaetoceros socialis forma radians RNA virus 1.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Marnaviridae; Bacillarnavirus.
OX NCBI_TaxID=2169725 {ECO:0000313|EMBL:BAH22517.1, ECO:0000313|Proteomes:UP000203516};
RN [1] {ECO:0000313|EMBL:BAH22517.1, ECO:0000313|Proteomes:UP000203516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19233955; DOI=10.1128/AEM.02580-08;
RA Tomaru Y., Takao Y., Suzuki H., Nagumo T., Nagasaki K.;
RT "Isolation and characterization of a single-stranded RNA virus infecting
RT the bloom-forming diatom Chaetoceros socialis.";
RL Appl. Environ. Microbiol. 75:2375-2381(2009).
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DR EMBL; AB469874; BAH22517.1; -; Genomic_RNA.
DR BRENDA; 2.7.7.48; 11634.
DR Proteomes; UP000203516; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23195; Marnaviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT TRANSMEM 752..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..589
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1407..1534
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 1690 AA; 191477 MW; 3DC5970E917E3999 CRC64;
MFDCLSDFGT ILENPCCAGY YFDSEFLKFT ACDLGFADPA LYEFYSESEE RSYRRGKYHK
HMEALARERK KDSNRAKKCG SKERAAMRRL KEEDMDSESA LGAFARDSCN EVYHRYRLFR
DNLDSEASTQ KALALIEDFF LLYFALKDCT SMTQFMSIMT IWLKSKCKVD SVKTLFEIAF
GVDTQEKVMA LLLSPFIKSG STTGEFSSET NEMLSDLSDS DFSEYSSESA SDEKKHIFLQ
FRDALGALSS TSKDVRSSPL FSQVSALVST VLALGFLSDT KTLRVSVKGM DLFRFNAAKG
HKNCADLLEV CIDTLKFLVE KGYACFTNGD TSAFFMVTDD GLKFDQDYVR ITSQQGYVRE
QDWIPSPWLD QSDYEQDLLN CIENCEILLK AAPKGERYLI IRRLETLKKC HVDFTQTYKC
KSGLRPAPFS FIIKGTSSIG KSTIVNNLIT FALQTCAKNE GKEDYIVNPD VICTLNEMDK
YHSDYQGHTQ AVLLDDLGNA NPDTIDVNPT VNIINFNNNI KRTAIMAEAE LKGKRALQPR
VLAATTNVDM ESMSRHFSLE PLSVLRRFNI HIEATVRPDW RVPGTTFING AKLRASAEED
NFFPDAWIFD IYEYIGENKS KENRKHQHFS KRYLKDREGK QLKRVGVAEL LELFRDYIPQ
YVESQKSVVS SSKKVYNQIL CPHGVFKSTC RCCQAMNSES LSESYEDIRS AISGLSFVPN
FDVLGYLPNF VLRSRVMNHL LSYRTIKENK RMFGLLNLFG LGVCIATNVF LPLRSYSMLS
SVIGANMFMF SFRKQQLWDR LNACHDTIPR LIDSINERQK KIGKMVVYFA VGVLALYSAY
RMMSGLMKLG KPTSQSDSVF NEDLTELTEN IWKSVPIAPL PSDLKNGHSY NDISFCVIRQ
LASVTVLDAI RERKTSFNGL FIDSNMMLIP YHERPQNKVT FCIKMIGGNC VSGKNFNVDL
TSVDCVPVGK IGDTDIGLVY IGNSGDMKNL VKFFPTNHSA HLTTTGMLWK DKQGVLKERK
CKFQQRACLT TKEGNRHANG FFYRMTLPSF RGLCGAVHVS NTRSKSFIAG MHLAGKSRVG
TMSGGGALTQ QEIYDAIESI QLNHPSHVKA VNTGLYESEA YGIQYPVEEM VSKKSPTNFM
SIDKNQAQVD VYGTLPSTHF VKPKSNVIKS PISDAVTKHC GIENQWGPPP NCRRKDQLNS
QPLWGPYQEY LDGVSEATQE FSTEVMDRAI NDYLDQIYRY AQTPRGKAAL EQVKILDPVA
IASGNDVKFI DAMKPNTSMG FPINRPKREF LVDLDPNEFP ERECPRMLDD VTMAIAETAR
TFYAMGKRAY PIFKACTKDE PTKMSKTKTR VFQAAPVSLQ YNLRRSCLPV WAFLSSSPIY
SECAVGVNSQ GCAWNELDRF LTSFGTNRIV AGDFKAYDQH MSARMVLISY YIVEQIAKLA
GYSDEECKLI RGMATDVAYP MMSLNGELIK LFGSNPSGQN GTVYTNSIVN SIYQRCVFFT
LYPEYEGNFQ DVVHLLTYGD DNKMGISPDF PKYNHTEMQK VYASVGIEYT MAEKEAESVP
LINHTEADFL KRKSRFEPKF TYVNNFGYRY KGMWLAMLDE GSIFKSLHAN LASSTISPIE
VACQAIDGAL REWWFYGRDV FELRQKQMIQ VITEMGLSDV VSQSVFDSFD KRETDWMIKY
GVEYVLDVEE
//
