ID PYRB_STACT Reviewed; 302 AA.
AC B9DPM9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE RecName: Full=Aspartate carbamoyltransferase;
DE EC=2.1.3.2;
DE AltName: Full=Aspartate transcarbamylase;
DE Short=ATCase;
GN Name=pyrB; OrderedLocusNames=Sca_0814;
OS Staphylococcus carnosus (strain TM300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=396513;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TM300;
RX PubMed=19060169; DOI=10.1128/AEM.01982-08;
RA Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G.,
RA Schuster S.C., Goetz F.;
RT "Genome analysis of the meat starter culture bacterium Staphylococcus
RT carnosus TM300.";
RL Appl. Environ. Microbiol. 75:811-822(2009).
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC + N-carbamoyl-L-aspartate.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR EMBL; AM295250; CAL27724.1; -; Genomic_DNA.
DR RefSeq; YP_002633909.1; NC_012121.1.
DR ProteinModelPortal; B9DPM9; -.
DR STRING; 396513.Sca_0814; -.
DR GeneID; 7551999; -.
DR KEGG; sca:Sca_0814; -.
DR PATRIC; 19602402; VBIStaCar105558_0815.
DR eggNOG; COG0540; -.
DR HOGENOM; HOG000022685; -.
DR KO; K00609; -.
DR OMA; MTLNAMR; -.
DR BioCyc; SCAR396513:GJ9G-829-MONOMER; -.
DR UniPathway; UPA00070; UER00116.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR HAMAP; MF_00001; Asp_carb_tr; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Pyrimidine biosynthesis; Transferase.
FT CHAIN 1 302 Aspartate carbamoyltransferase.
FT /FTId=PRO_1000116157.
SQ SEQUENCE 302 AA; 34388 MW; 746D4C12CB999999 CRC64;
MKQLVSMEDL TNEEIYSLIE TAIEYKKGNK PNKFTDKYVS NLFFENSTRT KCSFEMAERQ
LGLQEIPFET STSSVKKGES LYDTCKTLES IGVDALVIRH PQNDYYKELE GLNIPVINGG
DGSGQHPTQS LLDIMTIYEE YKDFKDLNVL ICGDIKNSRV ARSNYQALTA LGANVKFAAP
GEWVDESLDA PYVKIDDVIE ETDIVMLLRV QHERHDGELS FDPHEYHEKY GLTKDRYNRM
KSEAIVMHPA PVNRGVEIDS DLVEAPKARI FKQMKNGMFL RMSVITHILA EKEEGVIFDV
AN
//
