ID B9DU09_STRU0 Unreviewed; 333 AA.
AC B9DU09;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Catabolite control protein A {ECO:0000256|ARBA:ARBA00019435, ECO:0000256|RuleBase:RU368079};
GN Name=ccpA {ECO:0000313|EMBL:CAR41295.1};
GN Synonyms=alsA {ECO:0000313|EMBL:CAR41295.1}, amyR
GN {ECO:0000313|EMBL:CAR41295.1}, graR {ECO:0000313|EMBL:CAR41295.1};
GN OrderedLocusNames=SUB0536 {ECO:0000313|EMBL:CAR41295.1};
OS Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=218495 {ECO:0000313|EMBL:CAR41295.1, ECO:0000313|Proteomes:UP000000449};
RN [1] {ECO:0000313|Proteomes:UP000000449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-854 / 0140J {ECO:0000313|Proteomes:UP000000449};
RX PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA Parkhill J.;
RT "Evidence for niche adaptation in the genome of the bovine pathogen
RT Streptococcus uberis.";
RL BMC Genomics 10:54-54(2009).
CC -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC repression (CCR) and carbon catabolite activation (CCA), which ensures
CC optimal energy usage under diverse conditions.
CC {ECO:0000256|RuleBase:RU368079}.
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DR EMBL; AM946015; CAR41295.1; -; Genomic_DNA.
DR RefSeq; WP_012658062.1; NC_012004.1.
DR AlphaFoldDB; B9DU09; -.
DR STRING; 218495.SUB0536; -.
DR KEGG; sub:SUB0536; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_0_9; -.
DR OrthoDB; 9784962at2; -.
DR Proteomes; UP000000449; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06298; PBP1_CcpA; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR006377; CcpA.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR NCBIfam; TIGR01481; ccpA; 1.
DR PANTHER; PTHR30146:SF150; CATABOLITE CONTROL PROTEIN A; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|RuleBase:RU368079};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU368079};
KW Reference proteome {ECO:0000313|Proteomes:UP000000449};
KW Repressor {ECO:0000256|RuleBase:RU368079};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU368079};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU368079}.
FT DOMAIN 7..61
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 333 AA; 36663 MW; 09340D60BF0B8051 CRC64;
MNTDDTITIY DVAREAGVSM ATVSRVVNGN KNVKENTRKK VLEVIDRLDY RPNAVARGLA
SKKTTTVGVV IPNIANAYFS ILAKGIDDIA AMYKYNIVLA SSDEDDDKEV NVVNTLFAKQ
VDGIIFMGHH LTEKIRAEFS RSRTPIVLAG TVDLEHQLPS VNIDYQAAVA EVIDILAENH
KKIAFVSGPL IDDINGKVRL SGYKEGLKKN KLDYKEGLVF EANYSYKEGY ELAQRVINSG
ATAAYVGEDE LAAGLLNGLF AAGKSVPEDF EIITSNDSPV VEYTRPNLSS ISQPVYDLGA
VSMRMLTKIM NKEELEEKEI LLNHGIKRRG TTK
//
