ID B9DVA6_STRU0 Unreviewed; 311 AA.
AC B9DVA6;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Tagatose-6-phosphate kinase {ECO:0000256|PIRNR:PIRNR000535};
DE EC=2.7.1.144 {ECO:0000256|PIRNR:PIRNR000535};
GN Name=lacC1 {ECO:0000313|EMBL:CAR43135.1};
GN OrderedLocusNames=SUB1455 {ECO:0000313|EMBL:CAR43135.1};
OS Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=218495 {ECO:0000313|EMBL:CAR43135.1, ECO:0000313|Proteomes:UP000000449};
RN [1] {ECO:0000313|Proteomes:UP000000449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-854 / 0140J {ECO:0000313|Proteomes:UP000000449};
RX PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA Parkhill J.;
RT "Evidence for niche adaptation in the genome of the bovine pathogen
RT Streptococcus uberis.";
RL BMC Genomics 10:54-54(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC ChEBI:CHEBI:456216; EC=2.7.1.144;
CC Evidence={ECO:0000256|PIRNR:PIRNR000535};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 1/2. {ECO:0000256|PIRNR:PIRNR000535}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC subfamily. {ECO:0000256|PIRNR:PIRNR000535}.
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DR EMBL; AM946015; CAR43135.1; -; Genomic_DNA.
DR RefSeq; WP_015911767.1; NC_012004.1.
DR AlphaFoldDB; B9DVA6; -.
DR STRING; 218495.SUB1455; -.
DR KEGG; sub:SUB1455; -.
DR eggNOG; COG1105; Bacteria.
DR HOGENOM; CLU_050013_5_0_9; -.
DR OrthoDB; 9801219at2; -.
DR UniPathway; UPA00704; UER00715.
DR Proteomes; UP000000449; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01164; FruK_PfkB_like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR005926; LacC.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR NCBIfam; TIGR03168; 1-PFK; 1.
DR NCBIfam; TIGR01231; lacC; 1.
DR PANTHER; PTHR46566:SF5; 1-PHOSPHOFRUCTOKINASE; 1.
DR PANTHER; PTHR46566; 1-PHOSPHOFRUCTOKINASE-RELATED; 1.
DR Pfam; PF00294; PfkB; 1.
DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000535};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAR43135.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736,
KW ECO:0000256|PIRNR:PIRNR000535};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000535};
KW Reference proteome {ECO:0000313|Proteomes:UP000000449};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000535}.
FT DOMAIN 7..293
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 311 AA; 33831 MW; 1F5D1ACD89B10E5F CRC64;
MILTITLNPS VDISYPLEDF NLNTVNRVAL PKKTAGGKGL NVTRVLHEAG QEVVATGLIG
GQLGDYLSHQ LTESGIANQF LTIKGETRNC IAILHQGMQT EILENGPYVD IDEADAFTNH
LNLIIKQFDV VTISGSLPRG LEQNYYSKLI ATAKAYDKKV VLDCSGQALI EVLKGKAKPT
VIKPNKEELE QILGSNIKEG DLEHLKELLK SPIFEGIEWI IVSLGANGAF AKHLDTFYKV
TIPKITVANP VGSGDSTVAG IAWALQVADQ PETLLKKANV LGMLNAQEAM TGHVNMANYN
DLFEQLRVEE V
//
