GenomeNet

Database: UniProt
Entry: B9DZK4
LinkDB: B9DZK4
Original site: B9DZK4 
ID   ADDA_CLOK1              Reviewed;        1238 AA.
AC   B9DZK4;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   14-MAY-2014, entry version 39.
DE   RecName: Full=ATP-dependent helicase/nuclease subunit A;
DE            EC=3.1.-.-;
DE            EC=3.6.4.12;
DE   AltName: Full=ATP-dependent helicase/nuclease AddA;
GN   Name=addA; OrderedLocusNames=CKR_0628;
OS   Clostridium kluyveri (strain NBRC 12016).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=583346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12016;
RA   Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Vertes A.A., Yukawa H.;
RT   "Complete genome sequence of Clostridium kluyveri and comparative
RT   genomics of Clostridia species.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The heterodimer acts as both an ATP-dependent DNA
CC       helicase and an ATP-dependent, dual-direction single-stranded
CC       exonuclease. Recognizes the chi site generating a DNA molecule
CC       suitable for the initiation of homologous recombination. The AddA
CC       nuclease domain is required for chi fragment generation; this
CC       subunit has the helicase and 3' -> 5' nuclease activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- SUBUNIT: Heterodimer of AddA and AddB/RexB (By similarity).
CC   -!- SIMILARITY: Belongs to the helicase family. AddA subfamily.
CC   -!- SIMILARITY: Contains 1 uvrD-like helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 uvrD-like helicase C-terminal domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP009049; BAH05679.1; -; Genomic_DNA.
DR   RefSeq; YP_002471093.1; NC_011837.1.
DR   STRING; 583346.CKR_0628; -.
DR   EnsemblBacteria; BAH05679; BAH05679; CKR_0628.
DR   GeneID; 7274105; -.
DR   KEGG; ckr:CKR_0628; -.
DR   PATRIC; 19471012; VBICloKlu118830_0764.
DR   eggNOG; COG1074; -.
DR   HOGENOM; HOG000015621; -.
DR   KO; K16898; -.
DR   OrthoDB; EOG6HJ22G; -.
DR   BioCyc; CKLU583346:GJNQ-662-MONOMER; -.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 4.
DR   Gene3D; 3.90.320.10; -; 1.
DR   HAMAP; MF_01451; AddA; 1.
DR   InterPro; IPR014152; DNA_helicase_suAddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR011604; Exonuc_phg/RecB_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02785; addA_Gpos; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding.
FT   CHAIN         1   1238       ATP-dependent helicase/nuclease subunit
FT                                A.
FT                                /FTId=PRO_0000379259.
FT   DOMAIN        6    474       UvrD-like helicase ATP-binding.
FT   DOMAIN      512    811       UvrD-like helicase C-terminal.
FT   NP_BIND      27     34       ATP (By similarity).
SQ   SEQUENCE   1238 AA;  144811 MW;  A7C797B4897E5CCD CRC64;
     MINVNTKWTE TQKSAIFTPN CNLLVAAGAG TGKTAVLVER ILQKVINDSE EVDIDKLLVV
     TFTNAAASEM KERVGEALSK LLELNCTSKN LQRQLALLNQ SNIMTIHSFC LKVIKNNFHR
     IDLDPNFRIC DDTESKLLKQ DALLELFEEK YEEENLGFLN LADGYGGKND SKLQDIVLSL
     YEFSQGSPWP KRWLQDVLKD FNLGSDFDFG DTKWAKVLMH NVTVELKGCK NKMKNILNTI
     ENIEGLEHYL EPFKSDIESI DKLINITTWD EIRDEFIKLS FNKLPSKRTD PLVKSYKDKA
     RNTRDEVKKK LISIREDIIL CTDDIYENFK EVYPLMKSLT FLVMDFYEKY HNKKSERNMI
     DFNDIEHFCL EILTSKDKNG DIIPSEAALE YREYFEEIFI DEYQDSNEVQ EVIMNMISRK
     NIYANLFMVG DVKQSIYRFR QARPELFLEK YNSYDEKEGS KNRKIKLSEN FRSRKEIIDA
     INYIFKQIMC REVGELDYGE EECLKSSARY EPFEGNCGGD VELHVVDKKE NENKLEDENE
     EELLDAISVE ARLVASKINE LVNPSLDQYS FKVYDKEIDN YRSIMYKDIV ILMRATQNWA
     PAFVEELNNS GIPVFADTSV GYFQAIEIKT IISLLQIIDN PLQDIPFIAL LRSPIGGFSP
     EDLIDLRVVN REISFYEILK AIKEHSLELK YSLEHIDERL EYKVEQFFNK LCLWRRKVIH
     MPIDEFIWHI YIETGYYGFV GAMPGGIQRQ ANLRMLFERA KQYKNISYKG LFNFINFINK
     LKSSSTDMGN AKILGENENV VRIMSIHKSK GLEFPVIILS GAGKRFNLTD INKSVLFHKE
     LGLGPEYVNS ERHISYPTIV KQVLKRKLKM ETLSEEMRIL YVAFTRAKEK LIITGTVDNI
     ENTFQRWCEA AYCEEDKLPE YSLINSRNFL DWIGPAVARH PCGEIIRKVC PFEYNLNLIT
     GDDSKWKVFV YSKDNFKSTL DENIDEDIIG KIKSLELDNN KEIYKNEVYR RLNWTYKYEQ
     SSKIAAKFSV SELKRRFKLI DTENGIEFME PIYLKKPAFL RESKGLTPSE RGIVMHLVMQ
     HIDIDKVGSY EQIKEQVDKL VFREFITEAE AKSISVYKII KFFNSEIGIR MKKSNNVYRE
     VPFYMEIEST ELYKQLPQHI YRDEKVLIQG IIDCYFEENN ELILVDYKTD HVGDIDSIKE
     KYQVQIYYYG RALEKLTGKK VKKKYLYLFS KDYILDLS
//
DBGET integrated database retrieval system