GenomeNet

Database: UniProt
Entry: B9E299
LinkDB: B9E299
Original site: B9E299 
ID   ILVD_CLOK1              Reviewed;         556 AA.
AC   B9E299;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-SEP-2014, entry version 33.
DE   RecName: Full=Dihydroxy-acid dehydratase;
DE            Short=DAD;
DE            EC=4.2.1.9;
GN   Name=ilvD; OrderedLocusNames=CKR_1573;
OS   Clostridium kluyveri (strain NBRC 12016).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=583346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12016;
RA   Inui M., Nonaka H., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Vertes A.A., Yukawa H.;
RT   "Complete genome sequence of Clostridium kluyveri and comparative
RT   genomics of Clostridia species.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC       oxobutanoate + H(2)O.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 3/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 3/4.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP009049; BAH06624.1; -; Genomic_DNA.
DR   RefSeq; WP_012102089.1; NC_011837.1.
DR   RefSeq; YP_002472038.1; NC_011837.1.
DR   STRING; 583346.CKR_1573; -.
DR   EnsemblBacteria; BAH06624; BAH06624; CKR_1573.
DR   GeneID; 7273173; -.
DR   KEGG; ckr:CKR_1573; -.
DR   PATRIC; 19473020; VBICloKlu118830_1757.
DR   eggNOG; COG0129; -.
DR   HOGENOM; HOG000173155; -.
DR   KO; K01687; -.
DR   OrthoDB; EOG6MSS24; -.
DR   BioCyc; CKLU583346:GJNQ-1618-MONOMER; -.
DR   UniPathway; UPA00047; UER00057.
DR   UniPathway; UPA00049; UER00061.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00012; IlvD; 1.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR004404; DihydroxyA_deHydtase.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   PANTHER; PTHR21000; PTHR21000; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00110; ilvD; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Amino-acid biosynthesis;
KW   Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW   Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN         1    556       Dihydroxy-acid dehydratase.
FT                                /FTId=PRO_1000190660.
FT   METAL       119    119       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       191    191       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   556 AA;  58826 MW;  C7AF710A1BE73157 CRC64;
     MRSDVITKGT KSAPQRALLN ALGLTKEEIE RPLVGIVSSK NDIVPGHMNL DKIVEAVKTG
     VSMAGGTPIV FPAIAVCDGI AMGHQGMKYS LVTRDLIADS TEAMAMAHAF DALVMVPNCD
     KNVPGLLMAA ARLNIPTIFV SGGPMLAGKV DGCKVSFSSI SEAVGAFNGG KITEEKLEEF
     ESKVCPTCGS CSGMYTANSM NCLTEVLGMA LGGNGTIPAV YSDRIKLAKH AGMKIMELLE
     RNIRPRDVMT EAAFKNALTM DMALGCSTNS MLHLPAIAHE AGIELNVDMA NEISAKTPNL
     CHLAPAGHNY VEELNEAGGI YAVMNEINKL NLLSTDLITC TGKTVAENIK GCINKNKEVI
     RPVENPYSTT GGIAILKGNL APDSCVVKRS AVAPEMLKHE GPARVFDCEE DALNAINTGK
     IVAGDVVIIR YEGPKGGPGM REMLNPTSAI MGRGLGGSVA LITDGRFSGA TRGAAIGHVS
     PEAAVGGNIA LVEEGDIIKI DIEANSIDFE ISEEELERRR SNWKPRQPKI TTGYLARYAS
     MVTSGNRGAI LEIPKF
//
DBGET integrated database retrieval system