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Database: UniProt
Entry: B9HSG4_POPTR
LinkDB: B9HSG4_POPTR
Original site: B9HSG4_POPTR 
ID   B9HSG4_POPTR            Unreviewed;       122 AA.
AC   B9HSG4;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 2.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=dCTP pyrophosphatase 1 {ECO:0000256|PIRNR:PIRNR029826};
DE            EC=3.6.1.12 {ECO:0000256|PIRNR:PIRNR029826};
GN   ORFNames=POPTR_010G069700 {ECO:0000313|EMBL:PNT15158.1};
OS   Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS   trichocarpa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX   NCBI_TaxID=3694 {ECO:0000313|EMBL:PNT15158.1, ECO:0000313|Proteomes:UP000006729};
RN   [1] {ECO:0000313|EMBL:PNT15158.1, ECO:0000313|Proteomes:UP000006729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX   PubMed=16973872; DOI=10.1126/science.1128691;
RA   Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA   Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA   Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA   Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA   Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA   Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA   Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA   Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA   Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA   Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA   Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA   Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA   Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA   Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA   Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA   Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA   Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA   Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA   Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA   Rokhsar D.;
RT   "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL   Science 313:1596-1604(2006).
CC   -!- FUNCTION: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the
CC       corresponding nucleoside monophosphates. Has a strong preference for
CC       dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which
CC       it may even have a higher efficiency. May protect DNA or RNA against
CC       the incorporation of these genotoxic nucleotide analogs through their
CC       catabolism. {ECO:0000256|PIRNR:PIRNR029826}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dCTP + H2O = dCMP + diphosphate + H(+); Xref=Rhea:RHEA:22636,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57566, ChEBI:CHEBI:61481; EC=3.6.1.12;
CC         Evidence={ECO:0000256|PIRNR:PIRNR029826};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRNR:PIRNR029826};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|PIRNR:PIRNR029826}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|PIRNR:PIRNR029826}.
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DR   EMBL; CM009299; PNT15158.1; -; Genomic_DNA.
DR   RefSeq; XP_002314484.2; XM_002314448.2.
DR   AlphaFoldDB; B9HSG4; -.
DR   STRING; 3694.B9HSG4; -.
DR   GeneID; 7475400; -.
DR   KEGG; pop:7475400; -.
DR   eggNOG; ENOG502S28B; Eukaryota.
DR   HOGENOM; CLU_110454_0_3_1; -.
DR   InParanoid; B9HSG4; -.
DR   OMA; IRDNNDW; -.
DR   OrthoDB; 5485883at2759; -.
DR   Proteomes; UP000006729; Chromosome 10.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0047840; F:dCTP diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006253; P:dCTP catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0042262; P:DNA protection; IEA:UniProtKB-UniRule.
DR   CDD; cd11537; NTP-PPase_RS21-C6_like; 1.
DR   Gene3D; 1.10.287.1080; MazG-like; 1.
DR   InterPro; IPR025984; DCTPP.
DR   PANTHER; PTHR14552; -; 1.
DR   PANTHER; PTHR14552:SF2; DCTP PYROPHOSPHATASE 1; 1.
DR   Pfam; PF12643; MazG-like; 1.
DR   PIRSF; PIRSF029826; UCP029826_pph; 1.
DR   SUPFAM; SSF101386; all-alpha NTP pyrophosphatases; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR029826};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR029826};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR029826};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR029826};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006729}.
SQ   SEQUENCE   122 AA;  13872 MW;  755C0E380AAC7227 CRC64;
     MEEIEEISIA EEKVVDISLK DLAKKLEEFA KARDWEKYHS PRNLLLAMVG EVGELSEIFQ
     WKGEVDKGLP NWEESDKEHL AEELSDVLLY LIRLSDICGI DLGDAATKKI VKNAIKYPPK
     AC
//
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