ID B9KE70_CAMLR Unreviewed; 1040 AA.
AC B9KE70;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Multidrug efflux system CmeABC, inner membrane drug transporter CmeB {ECO:0000313|EMBL:ACM64858.2};
GN Name=cmeB {ECO:0000313|EMBL:ACM64858.2};
GN OrderedLocusNames=Cla_1559 {ECO:0000313|EMBL:ACM64858.2};
OS Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=306263 {ECO:0000313|EMBL:ACM64858.2, ECO:0000313|Proteomes:UP000007727};
RN [1] {ECO:0000313|EMBL:ACM64858.2, ECO:0000313|Proteomes:UP000007727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM2100 / D67 / ATCC BAA-1060
RC {ECO:0000313|Proteomes:UP000007727};
RX PubMed=18713059; DOI=10.1089/fpd.2008.0101;
RA Miller W.G., Wang G., Binnewies T.T., Parker C.T.;
RT "The complete genome sequence and analysis of the human pathogen
RT Campylobacter lari.";
RL Foodborne Pathog. Dis. 5:371-386(2008).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP000932; ACM64858.2; -; Genomic_DNA.
DR RefSeq; WP_012662241.1; NC_012039.1.
DR AlphaFoldDB; B9KE70; -.
DR STRING; 306263.Cla_1560; -.
DR GeneID; 7411306; -.
DR KEGG; cla:CLA_1559; -.
DR PATRIC; fig|306263.5.peg.1537; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_0_7; -.
DR Proteomes; UP000007727; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007727};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1040 AA; 113545 MW; C119AEDBE3D6E226 CRC64;
MFSKFFIERP VFASVVAIII SLAGIIGLYS LPVEQYPALT PPVVKVSATY SGADAQTVAQ
TVAIPLEDAI NGVENMIYMD STSSSSGDMS LSVYFNIGTD PDQATVDVNN RISAAMAKLP
EDVKKTGVSV RKTGSSILAV ASLYSPDGSM DELEVYNYAA LNILDDLARV PGVGNAVAIG
SRNYSMRIWL NPDLLNKYQV TATDVIAAVR EQNAQYATGK IGQEPVVERS PYVYSVTMQG
RLKNAKEFEN IILRTNSDGS FLRLKDVAEV GLGSREYTFN GRLNGNNATP ILIFLQTGAN
AVNTAELVKA KFEELSKSFP EGLAYKVPYD TTLFIKASIQ EVIKTFFEAL ILVVIVMYLF
LKNFRSTIIP MIAVPVSVLG TFAGLYVLGF SINLLTLFAL VLAIGIVVDD AIIVVENIDR
IIHEDENISI KDAAIQAMEE VAAPVVSIVL VLCAVFIPVS FISGFVGEIQ RQFAITLAVS
VTISGFVALT LTPSLCAIFL RRNESKPFYI VKKFNDIFDW SIEVFGAGVA YMLKRVVRFV
LVFFIFLIAL LGLFKIVPHS LVPNEDQGSF LSVVNLPAAS SLNRTTQAMD TLAEQLGKNE
NIENIVGLIG YDLFTGSLKE NSGAMFVNLK DWSERSVSSF DITGTYNKQY YLNPNFQSFF
VNPPPIQGLS LTGGFEMYAQ NRGGKSYDEI QADVNKLVDA ANKRPELSNV RTTLDTNFPQ
LKLEIDRDKV KLYGLNLNDV FSTLNATIGT YYVNDFSMLG KNYRVNISAI GDFRNTQNAL
KNIFVRANDG SMVALDSVLT LTRSVGPDDV KRFNLFPSAL VQGDPAPGYT SGQAIDAIAQ
VAKETLGEEY SIAWSGSAYQ EVTSSGAGQI AFALGLLFVF LILAAQYERW LMPLAVITAV
PFAVFGSLLF VWLRGIDNDI YFQTGLLLLI GLSAKNAILI VEFAMEEHLK KGKSIFDAAI
SAAKLRFRPI VMTSLAFICG ILPLVFAYGA GSASRHAIGT GVVGGMIAAS TVAIFFVPLF
FYILESFNKW LDEKRGKKHA
//
