ID B9KI60_ANAMF Unreviewed; 819 AA.
AC B9KI60;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982};
GN Name=mutS {ECO:0000313|EMBL:ACM49172.1};
GN OrderedLocusNames=AMF_301 {ECO:0000313|EMBL:ACM49172.1};
OS Anaplasma marginale (strain Florida).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Anaplasma.
OX NCBI_TaxID=320483 {ECO:0000313|EMBL:ACM49172.1, ECO:0000313|Proteomes:UP000007307};
RN [1] {ECO:0000313|EMBL:ACM49172.1, ECO:0000313|Proteomes:UP000007307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Florida {ECO:0000313|EMBL:ACM49172.1,
RC ECO:0000313|Proteomes:UP000007307};
RX PubMed=19134224; DOI=10.1186/1471-2164-10-16;
RA Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E.,
RA Palmer G.H., Knowles D.P. Jr., Brayton K.A.;
RT "Conservation in the face of diversity: multistrain analysis of an
RT intracellular bacterium.";
RL BMC Genomics 10:16-16(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001079; ACM49172.1; -; Genomic_DNA.
DR RefSeq; WP_012658895.1; NC_012026.1.
DR AlphaFoldDB; B9KI60; -.
DR STRING; 320483.AMF_301; -.
DR GeneID; 7398410; -.
DR KEGG; amf:AMF_301; -.
DR PATRIC; fig|320483.3.peg.354; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR Proteomes; UP000007307; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000007307}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 498..532
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 819 AA; 91080 MW; 1C18D7B85579B9DA CRC64;
MVKASDNTEY TPIIRQYKSL KDQYEGCLLF YRLGDFYELF FDDAVVASRA LDIVLTKRGA
GTPMCGIPTH SADSYLGRLV KLGHKVAICE QLETVEEARK RGHRALVKRD VVRIVTPGTL
LEDGLLEASE NNYLACLSRV GDSYGVAWMD LSAGIFNVRS SRLENIDSEI QRIRPRELLI
SDRLKEQREV ELILRRHRCA VTSHSESFFD VKKAEKVLCG IYGVNTLRGL GNFTDVEVSA
CGSLVEYVRT TQKNNLPKLG YPKVCDSKSF VLIDGAALRN LELFCTQSGE KEGALVSVID
RTVTAIGSRL LKRHLAFPSS CPHVINSRQD AVEFFVKSRN ICESIRDVMR GIPDMERILT
RIKLLKCSPR DVCMLGKALA KILRLQQIML EVDNPMLVRI VGEFGEHEKL LKLISGTILE
NNAANARDGG FINPACNARL ATVVRIESES DKLMQDLRDK YRKLTGIGSL KIAYNSVLGY
YIETPASHKL KDTIFIHRQS LAHTMRHTTA ELRELEETIT AAKSEIMELE AQIFRGLCLR
ISEEAQSVEL AANAVAELDV LISLARLAVE NKYVRPIVDD SREFAVKRGR HPVVETGVRF
IANDVNLSED GRMWLITGPN MAGKSTFLRQ NALIAILAHI GSFVPAESAH IGVIDKIFSR
VGASDSISLG YSTFMVEMAE TAAILNQATD RSLVILDEVG RGTGIHDGFS IALAVIEHIH
DVTKSRAICA THYHELPKFS SYLKNVQCFY MKIEEWQGQV VFLHELVAGI SGKSYGIYVA
ELAGFPKNVL ERARFFMGEL GESGSLSSNC EGLVGQHST
//
