ID B9M1M8_GEODF Unreviewed; 870 AA.
AC B9M1M8;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Synonyms=mutS-1 {ECO:0000313|EMBL:ACM21110.1};
GN OrderedLocusNames=Geob_2761 {ECO:0000313|EMBL:ACM21110.1};
OS Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) (Geobacter
OS daltonii).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=316067 {ECO:0000313|EMBL:ACM21110.1, ECO:0000313|Proteomes:UP000007721};
RN [1] {ECO:0000313|EMBL:ACM21110.1, ECO:0000313|Proteomes:UP000007721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22248 / JCM 15807 / FRC-32
RC {ECO:0000313|Proteomes:UP000007721};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Kostka J., Richardson P.;
RT "Complete sequence of Geobacter sp. FRC-32.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001390; ACM21110.1; -; Genomic_DNA.
DR RefSeq; WP_012647838.1; NC_011979.1.
DR AlphaFoldDB; B9M1M8; -.
DR STRING; 316067.Geob_2761; -.
DR KEGG; geo:Geob_2761; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_7; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000007721; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000007721}.
FT DOMAIN 696..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 622..629
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 870 AA; 96023 MW; 7EE2947E3DA7FF89 CRC64;
MSQITPMMRQ YLEIKADYPD AVLFFRLGDF YEMFLDDAVK ASRILDITLT SRNKNSDGAD
VPLCGIPYHS AGPYITKLIE AGEKVAICEQ VEDPKSAKGI VRREVVKVIT PGLVVDGSSL
SPKDNNYLLS IHNDDGNRWG LSYLDLSTGE FRLTELDSLD AVVAEIACVG PREILLPSFF
RDNGKMKELA RATAGLVVTH VEDWVYDHEY CRRLLAGHFA GASPSSLGCD GLVSGLYAVG
AVLHYLQETQ KGKAAHVTSI KAYTNAEHLL LDEATRRNLE LTATLAEGKR KGSLLGLMDR
TTTAMGGRKI KQWINYPLVT NRGITDRQDA VEALLQDAGS RAEIAALLNG VYDLERLNGR
ISLASAGAKD LVAMKDSLAR IPAIKEVLVA FSSNLLAGLN EGLNPLPELI ELIERGIVEN
PPFVLREGGI IADGYNAELD ELRAISREGK GFIARLEAQE KKRTGISSLK IRYNKVFGYY
IEVTRTNLDS IPADYIRKQT LANAERYITP ELKEYEDKVL GAEDRIRDLE FSLFQEIREA
AAGHGNLIAR TADCLATVDV LVSLAELAHE NNYCRPKVDD GTNLAIVDGR HPVIEALNQG
ERFVPNDTLL DNDENQIIVI TGPNMAGKST FMRQVALIVL MAHMGSFVPA TEARIGMVDR
IFTRVGASDN LARGQSTFMV EMMEAANILR NATPKSLVIL DEIGRGTSTF DGVSIAWAVA
EYLHDNGEHA AKTLFATHYH ELTELSVTRR RIKNFNIAVK EWNEQIIFLR KIVPGGASHS
YGIQVARLAG LPLEVIERAK EILVNLEKGE YAEEGIPRIA REKKATVPTS QLSLFQNTED
LLRKRLLSID VATLTPLEAL NLLDELKRMA
//
