ID B9PUT8_TOXGV Unreviewed; 834 AA.
AC B9PUT8; A0A0F7UUX1; B9QG29; S7W431;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=BT1 family protein {ECO:0000313|EMBL:ESS33054.1};
DE SubName: Full=BT1 transmembrane domain-containing protein {ECO:0000313|EMBL:CEL73957.1};
GN ORFNames=BN1205_047730 {ECO:0000313|EMBL:CEL73957.1}, TGVEG_201690
GN {ECO:0000313|EMBL:ESS33054.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS33054.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS33054.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS33054.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS33054.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS33054.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL73957.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL73957.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family.
CC {ECO:0000256|ARBA:ARBA00007015}.
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DR EMBL; LN714496; CEL73957.1; -; Genomic_DNA.
DR EMBL; AAYL02000119; ESS33054.1; -; Genomic_DNA.
DR AlphaFoldDB; B9PUT8; -.
DR STRING; 432359.B9PUT8; -.
DR PaxDb; 5811-TGME49_001690; -.
DR EnsemblProtists; ESS33054; ESS33054; TGVEG_201690.
DR VEuPathDB; ToxoDB:TGVEG_201690; -.
DR eggNOG; ENOG502QRK9; Eukaryota.
DR OMA; VRCEERN; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR31585:SF51; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 172..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 671..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 90131 MW; 2AB4579EED8A878C CRC64;
MSFHVATPSS PKCETAPDLF SLISSSNSPF TPSRYSSASS SSSSATSSAS SSSCVCSPND
ARCLICGRSS PALCGVSEPF PALPCLLPAS LCSSATSLVS TVVNCALPSR EVSPESAGGK
RSCRGWFRCI WSACVRAPRS VCSTAFIRWV FSVLLLPATL CRSVRKAVGS RFFLLLISVY
LCLKGLVYSL STAAMLPYFK GLGWQAAAYQ QATAIVFVPW GMKGLVGTLA DAIPLFGYRK
KYYMLIASVL GVGGVFGLCI LPDEFAADRL WLVCLLLLLV QLQVATLDLM CEGKYSELMV
EVPDVGPAVV TFVNALISVG QATGKMVVGP VSDRLGTRPL FWLALPLAVS VFVPICLNYL
PEKKLDHADL QVLRRHLWAQ KNVFVMGIAL ATASLGVAVV SLFEGQRILI IYSLCAGVAL
SLVCCLTLPK PIAHCNMYFF LDQVLHLNVA GALDFFYTAS PACLPDGPHF DYTYYNTYAC
IAGAIGGVVV LVLFLKVLPQ YSFRHILTTA CLVRLGASLV DYALVSRLTT ELHLSDKAVY
LVGDAVILVG ANALSYMVGV MLISKLCPKH VEVTVYAILA GMGNMGSTLS TLLGVAAIKE
FRITSKAEES CDFSRMPQLI SISNFILPSL CIPLCMTLLP NTAMNAPLPV TTELEETLEC
SCSFAQDAQS AEENGWRGGS EERAEDENSE GSDAECHGSG RANPNGDRES GYAEDRHTNG
NTQGNWRKRR ARRHARNREK EDERSRLVDE GRTAVGGVAC REGQGKDERP LRPREKRKEL
DVRQAPDEYE KCRNVVPVVS MLVGTELVGV RCEERNTSKR VGNGEESSTE DGEG
//
