ID B9PYE4_TOXGV Unreviewed; 10021 AA.
AC B9PYE4; A0A0F7UU18; B6KQX8; B9QL60; S7UI30; S8GL48;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Putative type I fatty acid synthase {ECO:0000313|EMBL:ESS29205.1};
DE EC=1.1.1.100 {ECO:0000313|EMBL:ESS29205.1};
DE EC=2.3.1.111 {ECO:0000313|EMBL:ESS29205.1};
DE EC=2.3.1.161 {ECO:0000313|EMBL:ESS29205.1};
DE EC=2.3.1.39 {ECO:0000313|EMBL:ESS29205.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:ESS29205.1};
DE EC=6.2.1.20 {ECO:0000313|EMBL:ESS29205.1};
DE SubName: Full=Type I fatty acid synthase, putative {ECO:0000313|EMBL:CEL71532.1};
GN ORFNames=BN1205_013030 {ECO:0000313|EMBL:CEL71532.1}, TGVEG_294820
GN {ECO:0000313|EMBL:ESS29205.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS29205.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS29205.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS29205.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS29205.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS29205.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL71532.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL71532.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714489; CEL71532.1; -; Genomic_DNA.
DR EMBL; AAYL02000310; ESS29205.1; -; Genomic_DNA.
DR STRING; 432359.B9PYE4; -.
DR PaxDb; 5811-TGME49_094820; -.
DR EnsemblProtists; ESS29205; ESS29205; TGVEG_294820.
DR VEuPathDB; ToxoDB:TGVEG_294820; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR eggNOG; KOG3628; Eukaryota.
DR OMA; MYPDPAA; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0008922; F:long-chain fatty acid [acyl-carrier-protein] ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0050637; F:lovastatin nonaketide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0050111; F:mycocerosate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 4.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd08955; KR_2_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 4.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 12.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 4.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08240; ADH_N; 2.
DR Pfam; PF00107; ADH_zinc_N; 4.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 4.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF14765; PS-DH; 4.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 4.
DR SMART; SM00829; PKS_ER; 4.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF50129; GroES-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 13.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:ESS29205.1};
KW Ligase {ECO:0000313|EMBL:ESS29205.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:ESS29205.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESS29205.1}.
FT DOMAIN 813..889
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 908..1335
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2979..3055
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3078..3504
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5148..5224
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5252..5673
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6899..6975
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6999..7427
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 9004..9081
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 694..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4166..4230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8694..8723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4166..4186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4192..4230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 10021 AA; 1093469 MW; 5C5AA4748CA6364A CRC64;
MMTRLPLCQQ QAPPSLAGCH MLAAFQDIPE RPLNRDLKEL WAAYGENPFG NVLECWNRSI
PDEDAVVWLN SDGEISETTT FSELFSRITR LSSFLRAAGL QVGDRIILCY PPGTDFVTAF
FACITSGFVA VPVYPPDPSK GLSDVPRFCD INEIAGCKTA LTNSLYKRVV QVITTVAKDS
RWRSVHWVCT DDVIKRHAEE AKNSVGPDFP NLSPHHPAFL QFTSGSTGNP KGVIVTHGSL
LHNCHLCWSA YQFPSHYEND GDDENITNHD FALVNQREFW RRRQEISIKS RGHRLRAFSW
LPVYHDMGLI GFVCSPILCG ATLYQMSPID FIRRPWLWLQ GMSKYDCICC AAPNFAFEVV
TRKMPDNVYE HLDLSRVCGF LSGAEPIRAS TIDRFCEKFG PKGVRRCAVC PAYGLAESTL
IVTARKTFQT VPKLLIVDSF QLQHEKTVVA LKPEATVTMD SEEYQVLVGC GVPLEGVQVR
IVDPETKKEL PPGKVGEIVV YSSSVARGYF GRPDTTKETF CYSFTDLQGK QTPPLGMRTG
DGGFMYEGEL FVAARLKDLI IIRGRNFYPQ DIEEAVDKVA MVRPGSSAAF AIEVDGHEAL
AVAAEVRLEE GIKGLWLRVK RQFDRSHYEQ IVRDISKSVA ANTGLTIHRI WLLRPRTIPK
TSSGKVRRSL TKEKLVSGKL EGILLDHAHH QHQAFYHDGP GGSRSRTRTG SGATPSGGAA
TRDGTASSNP SGDAHPKNSN TSNSITDSSH SVQRGSLRGD ACVAGGRLGP SASHGGVHHE
KDHKHRGDGS GMSSPDQVPG AGAAASESSA HVALTEKVKQ TVFEAAKTVL GSSEIPEIDA
PLHELGVDSI GAVEFSELIS AELQVDVEPT LLFNYPTLSD VIDFFVRELE GKGSEDLAVS
LEKTGARETT TAIIGAACNL PGGTTSLNAF WDLLMCGVDA IAEVPRSRWD VEEYFDPDPG
ADGKAYVREG GFIEDAEMFD AAFFRISPSE AKSMDPQQRL LLEVAYESLY DSGYTREGLQ
RASVGVFVGC CSNDWYQVCS QLELGISSYT TTSYAPSIIA NRLSYTFGLL GPSMTIDTAC
SSSLVALHIA AQELQGGSCM SAVVAGVNLM LSPHITVAFC KSRMLAPDAR CKTFDASANG
YVRGEGLGSI VMKRLSQAEK DDDRILCILR GTAVNHGGRS ASLTAPSGPS QQRVIRTALR
QAELTPGDIY FVETHGTGTS LGDPIEVGAL KSVFGASRDA KTKPLILGAA KTNIGHLEGA
AGIAGVLKAM LALRYKHIPP NLHFKQMNPH IDVREFNVVV PTAPMAFPRE DGGRLFAGVS
SFGFGGANGH VILQEALQQP SGDKPPCKRH SKRSIICFMF TGEGYEVSCM GRHLYETDDV
FKEIITKCND ILKRWLNVSL LSILYPPADK KMEMDKMMCQ ARFGHTALFA FEYALAESMV
SKGVKPDVVF GVGLGELVAA AFSGVMSLEE ALYVVTQRAK LIDNLPPFEG VMVACRVSEQ
EVEMALSEME INSRQSISIA AVYGRKNLIL SGEQSEIDNV LMKLNIAGRW KYLPVHNVLT
MNLVSDIIPP FTHLMSTVKL CRPKVRLVSS TTGEFVDKEA LSGRFWSRQV SQTVQLQQAV
GNIVASGCSL FVEIGPQVVL TKLAQQSLNG NAKDVTWVPA YDTTSDDVRV FENAVMTCNE
AIKIIGKERS LEEGQHGQEE LIFHRKPFPW TEIPHPFLSG HKFTEKDDVV FENAFPRRAI
PLIADHAVNG TAMMPGAGML EMVGAAALAL DLRTTSGAVS LENISFERPM LIGAHRVTYE
YNRRHSLGEG GGAGTSPRTV RTPRLVNHAY TRLGFREKSA EKAISETAGP ASTEGGRTPV
AGHHHGSYTK AGVLEDIKDY AHNVLRRAAQ HAEEIDVHTP VPPSMAPPSI VARHPREGSY
GSMSRTSGIM GSNDRGDGLT VPLSVEMAIR CRVTKMKEVE LSTVWDDEVT DHCFATIVIA
DKKQETYSSL QEVRCRCTER MDVNEYYDML YDAGLQYGPR FRTIQELYRG EKEALARVHF
VGNVKQDPFE SGFLIHPAVL DGALQAAGCL LEQSHSGNKV MVPVSVGSAT LTKVEVFQPC
WAHVRLEETK SKAATLNVTI YDEVTREVVA SLQNAVLRQV DPSASVVATI PKDLLWKVNW
QLVVEGDKEV VGRTPKVLFI GGNIELSEAL ENAMGSTCKT LSVDALPREK AELQKVLDAE
QWQAIVYVEA VTAGVYDALD VMNAAVRLVQ AHYLNLNSGK AVGALWFVTR DTVFRDNGAD
KPGVEIPAHA GLWGLAKAAR LEMEVSAGSP ISMGCLDVSG ADVSSMAQQI LHALKSKVLT
MRETEVAVRE DGLYVSRLAP QTEVDVRGAI EFHMPERGAI SNLVLRPQAF ASRLPPEDGQ
IELRVRAVGL NFRDVLNVMG LYPGDPGPPG ADCAGVVVAV GDNVEHIEVG DCVFGVAQGC
LRTYVTTDSQ LLRRMPESMT FEQAAALPVV ATTVEYALHD LAKVKAGDKV LIHAVTGGVG
LVAVQLCKRV GATVYGTCSG GKKDAFAKSM GVQYVSSSRD AKAFAEDMRT FLGEDGKVDV
VLNCLIDDFI PESLKLLGPY GRFMELGKRG VWSKEKVAAE RPDVQYELIA VDEMMEKDPI
WFGGMLVRVR GLVAEQKIQP LPMHVFDLAD TGENGGVAAF RFMQRAQHMG KVVLKIPSPV
EEASKNGSIV ITGGLGALGM VVAGWLAEEG ARHICLLSRR EEAPQPGEIP GWDWLRTINC
DVQFFSCDVS KYDSIRSVLR TIQTSVAPIT GIIHTAGALA DALLDSQTPE LMKKVYNGKV
QGAWNLNRAL EELGLNEQLK LCVFFSSVTS LFGNFGQANY CSANACLDAL AQWRRAKGLC
CQSIQWGPWI EQGMAAELKQ QVERNGMKGI SNEVGLRVLH DAIRQQEKAT PVIGCQAIKW
KLFMHRYIEQ PPFFTNIEMD LQVTSHDSNT VLRNLPPSER RDYIKAQVAA AARQVLGSSS
PPPFDTPLQD VGVDSLGAVE FRNVLSKKLG VKLSATTLFD YPTLNAIIDH LCEVFGESSQ
KDNLSTKLGA LSENDLVQEG MAIVSMSCRL PGNSTCPDLF WDMLMRCTDC VCDIPLTRWN
AEEVYSEDPD LPGKCYTRRG AFIENAEYFD NSFFGISPSE VKHMDPQQRL LLEVAYEAFA
GAGLTKEKLL GANIGVFVGA CNHDWTYLIQ EDKISAYTGT GSAGSVIANR VSYCLGLRGP
SVPVDTACSS SLVAADFAFE KLMLRDCTMA LVTGVNLMLT PHLFIAFSKA RMLSPDCKCK
TFDASADGYV RGEGAGAVLM LPYADAKAKQ MTIQAVVKGT ACNHVGRSAS LTAPNGPSQA
EVIRMALRRA GMKPNDLKFM ESHGTGTSLG DPIEVNAVRT VFAPGREKTK PLLIGAVKTN
IGHLEGSSGI AGLIKACLVL SRREIPPNLH FKTLNPHINI EDFPVQFVTD FVSLDSVEST
RKKNTAGVSS FGFGGVNAHV LLEEATRDQN ATRKEENRPK ICFMFTGQGS QYVGMGRHLY
EKEPVFREAI TRCVEIAKEY LPLPLLSVIY PSPDERDKMQ EAINETLYSQ PAVFVISYAL
LELWKSRGVE PDMVMGHSLG EYIAAVCSGV ISIQDGLKLV LKRAQIMSRA PSRNGVMVAC
RATAEQVEEA IHTLFGDGEK NVALASVNGL KSVIVSGNQQ DVQAVLRQLG AASRAKMLRV
SHAFHSPLVK DTVAPFKRVL ETVRLSKPRV MFVSTVTGKV ARDELQNTNY WAEHITKVVR
FCDAVQACIA QGAKIMVEVG PRPTLSNMGK GCLPQTTADE VQWINSLEPE TLSSAVFDSL
SALAKAGSGA MPAVFDRKFF PWTETCHPLL GGKNTRPDGS VVYSALLRDL VKALFLDHVV
YGKALLPATC LIEMMASATT HMISNHDEEK LVALSQVVFE KPLLVPDETS LSVLVTVETR
GQVRVASQVS NSEEEAEDHA VCQVNIVDAL PAAPALTEIR ARCKTEIEAS QLYAQLHNVG
LQYGPRFQTI VKVFKGEDEV LGLLQAQNVT NFETGFMMHP AVLDGALQLS AVLAFEKGSS
RAMVPFGVDT VLLKSCPPDK ELWARVVMNR KGVSSASATV HLYDFDGEPI AVLMGVTLRP
IEFNTAADIP RELLWEVEWE SAGSYSMPQD GSLATPSGTD DSGAEDVTRT PSPLVTGENE
NTPSREVPSA LPGLSTETPR ASKPLSTDET SGAVLNKSVH SVLLVDYAGG HREVVASIRD
TCDVEVEVLS KPGSPELYAQ QLRQFAEVVA TKTETVPLST ILFLALDEAT PAEQLAGGLL
ETVKVFAVEK FKKLPCIWVL TSGAQGPTRS VVSPKHAGLW GLMRTVRLEL EMQIGKMVRF
GCVDLDKNLE VSVALHFILQ KRTEEPFEAE MILRCPSEDS EKEPGTAEVV NRRERSASFV
SVGPEPVVPS TTDASAKSSV TSDRMALTPG ALSCFDETAN STEKLIFNAF CPRLHRSPIP
VRGAVELHMP ERGAISNLVL RPQAFASRTA PQSHECEIRV RAIGLNFRDV LNVMGLYPGD
PGPPGADCAG TVVAVGSGVR HLKVGDSVYG IAQGCLRTYV TTNGNLMRRM PESLTFEQSA
ALPVVAATVE YALHDLAKVK EGDKVLIHAV TGGVGLAALQ FCKRVGATVY GTCSGGKKAA
YAKSLGVKYL TSSRDASAFA EDMREFLGEE EKIDVVLNSL IDNFIPESVK LLAPGGRFME
LGKRGIWTKA QMAAERPDVY YETIAVDTMM QEDTVWFGGM LDRIRDHVDS GNIPPLPLHV
FEMTDPLAGG VAAFRFMQRA QHIGKVVIRI ASDLEVKIPS TTEPAATETA MLAEAGTQGN
ASIGTSTQQI ADRTYLITGG MGGLGLVVAQ WLVEEGARHI VLLSRRGEPS DTVKQSSIWE
YLTEKERTCV SVLPLKCDVS VKDDIVSAVK EIEARGFPPI RGIFHAAGVT ADASLANQTR
EAIEQVYLPK VTGAWNLHEV CESMGLDKNL DMFVMFSSVA ALLGNFGQAN YSAANACLDA
LAEYRRARGL CAQSIQWGPW IEQGMAADLR QALDKVGMRG ISNELGTRVL SEVVRNPRRA
TTVLCQSVIW KKFLQRYERV PPLFKNTRAG QGATADSSLM LRTMTAEERR AYVEKTVREV
VKQALGLADS PPMDLPMQEL GIDSIGAVEL RNALSSRLGV KMPATAMFDY PTLDAMVDYI
NSTLAEQCAG TEQDVSAETQ MNLVPQIMHR LEGNIAVTSV AVHLPGSVHN AEEFWDMMHQ
MRDCITEVPL TRWNMYTFFD PDPDTLDTSY AKLGGFIEDA DMFDNTCFNI SPAEVRVMDP
QQRIILEVAY EAMVSAGYTS SGQASQQSIG CFIGCCNADW HMLDVPSGPF TGTGSSTSII
SNRISYTLGL RGPSLTVDTA CSSSLVAMDN AMCKIIEGSC SAALVGGVNL MLSPHLFICF
SKARMLSPDC RCRTFDHRAN GYARGEGAGA VFLKPLQAAR KDDSTILAVV RGSAINHDGR
SASLTAPNGP AQQAVIRAAL QSGGVKPADI TVLESHGTGT QLGDPIEVGA IKAVFMHHRG
ADNPIYIGAL KTNIGHLEGA AGIASFIKLV LCLRRRELPA NLHFQQLNPH IDMTDFSAVF
PKATVDLPVT RKLFAGVSSF GFGGANAHVV IEEHFELSNA AEAPQKQTAP VKRERRSFPW
YQAFHPMLGH ETKTEVDERK IDMEIRRDVF DLLAQHMVEG RPVMPAACYL ETLTSAACTS
EFLHPCSRKM LRPNHHAAVT LEDIEFQRPM ILEAPEGHGH QIFQILTASL GPNGNASISS
LKTGDEEQFI HATCRLSSVN DTTAFTRTPE ENLKFLDEDT NRVPVDVGEM YEKLWKNGLM
LGPQFRTIHS IECSPRTAKV KLQLPQTPTS CELGFRMHPC VLDGTFQTVG PLVLAHDEQA
RKDGSSSNVG TMKLMIPFMI QRITLTSMHG VSNALWAHVA LVKRESNQAI VNIDIMSMTG
EPVCCLKELT MRRLDPVPVA EIPRELTWTV DWEEGQNVDP VPANAVEVVA IDPLGMQHTV
IKELKQKGFA SVQVFERDSS VEEVLRVLRI SSSGDSPTSL TPASAAAGEA AKSTSLPHRV
VLFLGTGGAN DAIEALDCLL QLSSGLEKAA KEDRQQEFYP IWILTKGSQS HRDKGRVSNP
VHAGLWGFAR TARLEISAQT SKEASIGCVD LGPECRVADV VQHLAAIQSQ EKYEREILFD
EVEEVEDQKR EKGKPPSGSK RLKHFVSRLA RSPLNVRGAL ELHMSDRGSI TNLTLRPQSY
AARVTPKGDM VELRVRAVGL NFRDVLNVMN LYPGDPGPPG SDCAGTVVAV GDRVKHLKVG
DSVYGVAPGC LKTYVTTNSQ IIRKMPASMS FEEAAALPVV ATTVEYVLND LAKVRAGEKV
LIHAVSGGVG IAAVQFCKRV GAVVYGTCSS EKKREFVESL GVKYVASSRD PEKFTAEMKT
FLGEEGRVDV VLNSLIDKFI PASLALLGKD GRFIELGKRG IWTHEQMRAQ RPDVYYEAVA
IDVMISENPR WFGIMLDRVR TLVERKQLLS LPLTVFNMND PNEGGVAAFR FMQKAQHVGK
VVVAIPSALD FERSTVGPPT TPQKTYVITG GMGGLGLVVA QWLVEEGARH IVLLSRRGEP
SDTVKQSSIW EYLTEKERTC VSVLPLKCDV SVKDDIVSAV KEIEARGFPP IRGIFHAAGV
TADASLANQT REAIEQVYLP KVTGAWNLHE VCESMGLDKN LDMFVMFSSV AALLGNFGQA
NYSAANACLD ALAEYRRARG LCAQSIQWGP WIEQGMAADL KALAEKAGLR GISNELGIRV
LVEAVRNSKT VVTFLAQSFI WKRFVQRFDV VPPFFSNIEF ETASPGAFRV LYSSMTPDEL
HTYVSNVVLD TARQVLGTSE LPALDSPLQE LGIDSLGAVE LRNSLSQRLG VKLSATTLFD
YPTIRAIIDY IVNQVSGEAS AAKATSGALV SAGLAAGRNS PIAVVGYSCR LPQGSETPDK
LWEMLRRAQD CVVEVPLTRF DVDMFYDSDI DAKGKMYVRK ACFMDDADMF DNSFFNISAA
EVTYMDPQQR VMLEVAYDAF YSAAYSREHL IGKNYGVWIG CCNSDWHFLE QQSNPDKSSS
YSGPGGSGCL VSNRLSYVFG LKGPSMTIDT ACSSSLVAAD CGAQAMRFGY CDGALIGGVN
LMLSPQLFLA FCKARMLSPD CRCATFDEKA NGYVRGEGAG AIMLRHLADA QREGKRILGI
VRGTAVNHDG RSASLTAPNG PAQQDVIRSA LQIGGVDPLD VALVESHGTG TALGDPIEMG
AIKAVYGAGR SADSPLVVGA LKSYIGHLEG SSGIAGILKV LLCLRHHEVP PNLHFDTPNP
HMDLSDFHVV LPKKQMKLQP AQKSSTILGS VSSFGFGGAN AHVVFEEYPE PTMATDVGGE
RRSTEAAESA GKKRLAFLFT GQGSQYPNMC KQLYEEEPVF RSHMDACFTV LEGKLDVKLR
DVIYPTAEND VEMLNLLNQT GYSQPAIFCV EYALAQLMIS KGFSPSVVMG HSLGEYAAAA
IAGVMDWKDA LLLVHERASI MQHIDPNDGV MYACRASEQD AQAAVEKALG EKAVAVTVSA
INGPRSIVLA GTQPDVLAVL KAMDMQSRAK QLTVSHAFHC PLVGEAAALL LPKVESVKLS
NPNEGITFIS TVTGKAVGAG ELTKPEYWAT HITKPVQFLQ GMRAAVTSGE AGIFIEIGPR
PTLVNMGQQC VPRNDYTWVA PVDPKDSNRN SFPQALEKIT SNMVCTYTWK RHAFPWTVVV
HPFVDKFVPD QDETKATSQK LLTPAVGELL HDHVVNGTAM MPGVGFLEAM AAGGFMMVDG
KLPSTVVALR DCEFERPMLI PKIDPSTGEF TQAAKLMITV NNKDITLKSI MDGEEEEIFH
SRCTFSLCPA TSLPTEPADL LTSLQGRITT PVPITTLYET LQSVGLQYGA RFQSIRECYA
AASDEVLAKL RPKLPLHSFE RNFRIHPVLL DGALQTAAVL FAEMGHKRPL VPVGVKRALL
ARVPAGSEVW SHVVVKSKDL RSATMDVTLF STKGTILGQL VDVAVRAFDA VAGAQIPKGL
LWEVSWVPKA KAPVEDGVDT VENEASETIT PTAKLAVKPT GKVEGLARQP AVNGQPKWLL
LKTPSSMLEG LQKALQGTPS AFVKELDEKH PNNAISSKIH NSEWDAIIYL GALSAAASST
TCVADALLLA NTLGNTAAEK PLPNVLFVTQ GQHFIRECGD VPTTAVPTQT GLYGFCRSAQ
LELENIIGRP VYLGTLDFAA KDPTLDDPAA FVSALQRVLA EADPTGAAGT CEPHTVIRGG
KEMVPRLVKS SIECRGAVEL HMSDRGALSM LKLRPMPKSA RVPPPRDCVE IRVRAVGLNF
RDVLNVMGLY PGDPGPPGAD CAGTVVAVGE GVEHLRVGDA VFGIAQGALK TFVTTSAHLV
RPLPGRLTFE QAAALPVVAS TVEYALHDVA KVKKGDKVLI HAVTGGVGLA AVQFCKRVGA
EIYGTCSGGK KEEFARSVGV KYITSSRDPK KFAEDMCEFL GNGKHKIDVV LNCLIENYIP
ETLKFLAPNG RFVELGKRGI WTREQMGTVR PDVLYETVAI DTMMEEDPVW FGGMLDRIRN
LVDGSMLQPL PLHTFEMTDS SEGGVAAFRF LQRAQHIGKV VIRLSSALEV KNFTTNSRQE
TENEDSGERH TLSPATAVGK PLSQSVADQM HKTYIITGGT GGLGLVVAQW LIEEGAHNIV
LLSRRGEPPS SVKAGDPVWK YLCGEEQPNC ISVATLKCDV SQKDDLLRVF KEIESRGLPP
VAGIFHAAGV TADAALASQT ADSVDQVYLP KAIGAWNLHD ACEALGLNKS LEVFMMFSSV
AALLGNFGQA NYSAANACLD ALAMYRQSLG LCGQSIQWGP WIEQGMAAQL TQHLEKVGMR
GITNELGLRV LGDVMMHPTV AVVGAQSLQW RKFLRRYAFE MPSFFSLVPM AGAGSSEASV
NLATITKEDL CELISSLAQA VSGAAEKPAV DTPLMDLGLD SLGAVEFRNS VADKVGVKLP
QNLMFENPSI SSISDYILDK AAGKHGESGV TGANGGSGEG SDIPALDTPL DQWLMSVLEP
AERFALYIDS FASEYGTLQK MAAEEDIITA LEDLGVEDGG DFERLHVAWD DLCNQINTAK
RMAAKDIRPS STAVSVSDHP KPRMPHPMED VDTLLASLDF DVSTLRPATA PDKVKNVLLT
GVTGFVGRVQ LASLMQLKQR PDLRVYCLVR ARNADHALSR IREATKEAKC WQETFVSRIV
PVTGDFTQPL LGLSSEEFQE LARKIDIVYH TGGDVNLLSN YGRLRATNVL SVKAIIDLCT
TYKVKPLHFA STLGQFPAFF AMFTGHFSGE SIREDSTPDV SQMENFYPPS RQGYPWSKWA
AERVLEGARK RGLPVAIYRL PNTYVAYKTG YTNKTDYATA LMIASIQEGV FPIGAATAPL
TPVDTICDML VEASFLEKPK HWVYHLFDPR LVTRADLEQW SQELGISYVG VKVDEFLEAI
KKRGPESPVF KFVPLMQHWR RFWFDPEERT ESFPISNEHI FEDLPHMRWP SLREVFKNSL
LYSVRMGFFP KNSKSIILDP QVALNEARRI CGLQLMGREG EDFFLHPWRV LQESARRECD
LLFGGQLAVY RTVRHYFMNV MYLADAQAKC PEIEKQEIQA PLIIVGLNRT GTTFLQNLMS
TDPSNRSLRY CEMIAPYGPD GNYRPKGLPN TEESWKKDPR IPFAQEILDS QLGLSEEWMA
IHTQRAELPE EDFVIFEHCG RCYSICTEFS VPSYREWLAS DNYKETRKAY SFHKRFLQHL
QWQRPAKRWL LKMPFHLFTL EALFETYPDA KIIFMHRDPK ETMGSWASLV KHAQQSLMDN
VDPSALGREE LRAMSTMINR ALAFRRSHPE LGPRFLDVQY QDLVNNPIGV VKSIYKHFGI
PLTLAAQTGI ASFCNENRKH RDKLTKHMYS LKDVDLTDGM VQEAFKEYYD SGLCKYLSSA
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