ID B9QHC5_TOXGV Unreviewed; 1162 AA.
AC B9QHC5; A0A0F7UU74;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cation channel family transporter {ECO:0000313|EMBL:ESS30072.1};
GN ORFNames=BN1205_052720 {ECO:0000313|EMBL:CEL71931.1}, TGVEG_222060
GN {ECO:0000313|EMBL:ESS30072.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS30072.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS30072.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS30072.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS30072.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS30072.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL71931.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL71931.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714491; CEL71931.1; -; Genomic_DNA.
DR EMBL; AAYL02000267; ESS30072.1; -; Genomic_DNA.
DR AlphaFoldDB; B9QHC5; -.
DR STRING; 432359.B9QHC5; -.
DR PaxDb; 5811-TGME49_022060; -.
DR EnsemblProtists; ESS30072; ESS30072; TGVEG_222060.
DR VEuPathDB; ToxoDB:TGVEG_222060; -.
DR eggNOG; KOG2302; Eukaryota.
DR HOGENOM; CLU_276658_0_0_1; -.
DR OMA; HKSHIPR; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 435..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..689
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 127875 MW; E5E7CBC05CBAA901 CRC64;
MPKKGANSSL PTAATSLDRS SREKRHVQPP DEGSRASAAA GTANPQSGLL AVTGEVQDRG
AETRWASRGR LPQGRDEARS PPPPSLPTSV QPTPASEEGQ SGCTRGSLAP QLGQHFSVSP
AAVDATPDKA ADSAATAPAS ARLPSPSSSE TASALRGHWH KSHIPRFSEQ RTNHPAGSSP
PSGSSPPSGS SPLSGSSPLS VSPSLAHVPS PSPPSVSVEL QSPHEASAES GLAEEFRCRM
SSVSDSMGGA RVASSGPPVG ETFGASSPFT ADGEARWFSE PSSRRRRNRT SLTLRLRASG
HSAQGRGCGG ARSSRGGRPG SRSRGFSNSL GGVRMPLVRG TEGRRTVAAG KSVVKHNASK
ALQALQAVQA EIDRGEQLQS MLGIQKYTEE KKLKELAALE QTEDYAEQLT CDLKLLRYYT
NTEAEIELRD RRARAFVYTP LAQIFMAVII ILNVIFLGVS TLEVYSREYV WDDNRTNLTV
KRDTPLFATF CFLNFFFAIV FFWEMVLRVK CDKAAYFNDI VNVSDFVNAW FGIADLFIVS
VGVFQKLDND ILNSFVALLK LARLLRVLRF IRILKSFLPM RVLVEGMESS FFSLLYAAAF
FLIFIYGFAV FFTTAFGYTA EVKEYWGDLF SSMYSLFLIL TMTNWDVIAE RTSVYFSWAK
VAIILYTVFS YFVLFNVVTA VIVEAFSTTA GRLEEEASHF SMFTDFRVNE QCFKSAMGGA
HLLRSRREES LRQRSREYLD FRKDLPADLL TNESGGTRWP RRSESSIWRQ HEPVRRRSVE
PQKRCSKEFR EARCGCPDTE EATREEETKL GSAAPSVMSR LAARLWRMRR RVGSLRRALK
VRSRSLELLE EAAPHSYEDD SLPRWSSFGA SASGVANPDG GRVPETENDG RLHSIEEISH
DAESPLPEPL LTSTAAQPQA PSPTAEPSAN QSGDASAPGR GIEVGSGEGP PSCLASQFNT
ASREDTAPRD CGGQQSGNRS ECTWETASVR DDGPGAWRAN RMRRRVRHTG DDSSSYSESK
VQRVPNNLDE AFVDIVPESP YLDLVRNHPL QILGERRVQL AMRKCRISYI QAYDCLTILA
QKGFEEITVS GFLTCCKRVS GTPTARQLFL LELDLERALR HLDHKTSRML SLLKLLVRQQ
GIYGSDNNAF QFSATTTRDT NG
//
