ID B9R9I0_RICCO Unreviewed; 364 AA.
AC B9R9I0;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Alcohol dehydrogenase, putative {ECO:0000313|EMBL:EEF51457.1};
DE EC=1.1.1.14 {ECO:0000313|EMBL:EEF51457.1};
GN ORFNames=RCOM_1497640 {ECO:0000313|EMBL:EEF51457.1};
OS Ricinus communis (Castor bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC Ricinus.
OX NCBI_TaxID=3988 {ECO:0000313|Proteomes:UP000008311};
RN [1] {ECO:0000313|Proteomes:UP000008311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Hale {ECO:0000313|Proteomes:UP000008311};
RX PubMed=20729833; DOI=10.1038/nbt.1674;
RA Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA Rabinowicz P.D.;
RT "Draft genome sequence of the oilseed species Ricinus communis.";
RL Nat. Biotechnol. 28:951-956(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; EQ973773; EEF51457.1; -; Genomic_DNA.
DR RefSeq; XP_002510855.1; XM_002510809.2.
DR AlphaFoldDB; B9R9I0; -.
DR STRING; 3988.B9R9I0; -.
DR GeneID; 8258311; -.
DR KEGG; rcu:8258311; -.
DR eggNOG; KOG0024; Eukaryota.
DR InParanoid; B9R9I0; -.
DR OrthoDB; 3017546at2759; -.
DR Proteomes; UP000008311; Unassembled WGS sequence.
DR GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd05285; sorbitol_DH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR045306; SDH-like.
DR PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43161:SF9; SORBITOL DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEF51457.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008311};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 25..362
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 364 AA; 39052 MW; 5159F6173252775E CRC64;
MGKGGMSHGE NKDVQEENLA AWLLGVNTLK IQPFKLPSLG PNDVRVRMKA VGICGSDVHY
LKTLRCAHFV VEEPMVIGHE CAGIIEGVGS EVKNLVPGDR VALEPGISCW RCDLCKEGRY
NLCPEMKFFA TPPVHGSLAN QVVHPADLCF RLPENVSLEE GAMCEPLSVG VHACRRANIG
PETNVLVMGA GPIGLVTMLA ARAFGAPRIV IVDVDDYRLS VAKDLGADAI VKVSTSIQDV
ADEVVLIHKA MGTGVDVTLD CAGFNKTMSS ALSATRSGGK VCLVGMGHNE MTVPLTPAAA
REVDVIGVFR YKNTWPLCLE FLRSGKIDVK PLITHRFGFS QKEVEAAFET SARGGDAIKV
MFNL
//
