ID B9S7M1_RICCO Unreviewed; 393 AA.
AC B9S7M1;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Peroxisome biogenesis protein 12 {ECO:0000256|PIRNR:PIRNR038074};
DE AltName: Full=Peroxin-12 {ECO:0000256|PIRNR:PIRNR038074};
GN ORFNames=RCOM_0609720 {ECO:0000313|EMBL:EEF40394.1};
OS Ricinus communis (Castor bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC Ricinus.
OX NCBI_TaxID=3988 {ECO:0000313|Proteomes:UP000008311};
RN [1] {ECO:0000313|Proteomes:UP000008311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Hale {ECO:0000313|Proteomes:UP000008311};
RX PubMed=20729833; DOI=10.1038/nbt.1674;
RA Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA Rabinowicz P.D.;
RT "Draft genome sequence of the oilseed species Ricinus communis.";
RL Nat. Biotechnol. 28:951-956(2010).
CC -!- FUNCTION: Component of a retrotranslocation channel required for
CC peroxisome organization by mediating export of the PEX5 receptor from
CC peroxisomes to the cytosol, thereby promoting PEX5 recycling.
CC {ECO:0000256|PIRNR:PIRNR038074}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704, ECO:0000256|PIRNR:PIRNR038074}.
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DR EMBL; EQ973886; EEF40394.1; -; Genomic_DNA.
DR RefSeq; XP_002521990.1; XM_002521944.2.
DR AlphaFoldDB; B9S7M1; -.
DR STRING; 3988.B9S7M1; -.
DR GeneID; 8258638; -.
DR KEGG; rcu:8258638; -.
DR eggNOG; KOG0826; Eukaryota.
DR InParanoid; B9S7M1; -.
DR OrthoDB; 65730at2759; -.
DR Proteomes; UP000008311; Unassembled WGS sequence.
DR GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR CDD; cd16451; mRING_PEX12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017375; PEX12.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12888:SF0; PEROXISOME ASSEMBLY PROTEIN 12; 1.
DR PANTHER; PTHR12888; PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038074};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140, ECO:0000256|PIRNR:PIRNR038074};
KW Reference proteome {ECO:0000313|Proteomes:UP000008311};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 21..303
FT /note="Pex N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04757"
SQ SEQUENCE 393 AA; 44407 MW; 2AAFFA161A1E64B9 CRC64;
MLFQVGGQGT RPTFFEMAAA QQLPTSLRAA LTYSIGVLAL RRPLLHKVLD YEDEFFALFM
LVLETHSLRT TDASFSESLY GLRRRGVKIQ VKKKDARLNL GDGIELSGLQ KRQRILSVAF
LVVLPYFKSK LYSLYNKERE ARLQASLWGD GGGPFEGTDY FDRDDGSLVS RGTMESEATI
RARLTKRIQK IIFACYPWVH ATSEGLSFTY QLLYLLDATG FYSLGLHALG IHVCRATGQE
LMDTSSRISK IRSRERERLR GPPWLKTLQG ALLSCTYAVL DYAQTGLIAA VFFFKMMEWW
YQSAEERMSA PTVYPSPPPP PPPKVAKEGI PLPPDRTICP LCAQKRANPS VVTVSGFVFC
YPCIFKYVSQ YTRCPVTLMS ATTEQIRRLF HDV
//
