ID B9T8N6_RICCO Unreviewed; 962 AA.
AC B9T8N6;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Vacuolar protein sorting-associated protein 11 homolog {ECO:0000256|PIRNR:PIRNR007860};
GN ORFNames=RCOM_0416040 {ECO:0000313|EMBL:EEF27778.1};
OS Ricinus communis (Castor bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC Ricinus.
OX NCBI_TaxID=3988 {ECO:0000313|Proteomes:UP000008311};
RN [1] {ECO:0000313|Proteomes:UP000008311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Hale {ECO:0000313|Proteomes:UP000008311};
RX PubMed=20729833; DOI=10.1038/nbt.1674;
RA Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA Rabinowicz P.D.;
RT "Draft genome sequence of the oilseed species Ricinus communis.";
RL Nat. Biotechnol. 28:951-956(2010).
CC -!- FUNCTION: Involved in regulating membrane fusion at the tonoplast and
CC the prevacuolar compartment. {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SUBUNIT: Core component of at least two putative endosomal tethering
CC complexes, the homotypic fusion and vacuole protein sorting (HOPS)
CC complex and the class C core vacuole/endosome tethering (CORVET)
CC complex. {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|PIRNR:PIRNR007860};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR007860}.
CC Prevacuolar compartment membrane {ECO:0000256|PIRNR:PIRNR007860};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SIMILARITY: Belongs to the VPS11 family.
CC {ECO:0000256|ARBA:ARBA00007070, ECO:0000256|PIRNR:PIRNR007860}.
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DR EMBL; EQ975130; EEF27778.1; -; Genomic_DNA.
DR RefSeq; XP_002534605.1; XM_002534559.2.
DR AlphaFoldDB; B9T8N6; -.
DR STRING; 3988.B9T8N6; -.
DR GeneID; 8287949; -.
DR KEGG; rcu:8287949; -.
DR eggNOG; KOG2114; Eukaryota.
DR InParanoid; B9T8N6; -.
DR OrthoDB; 5491867at2759; -.
DR Proteomes; UP000008311; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0009705; C:plant-type vacuole membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR Pfam; PF17122; zf-C3H2C3; 1.
DR PIRSF; PIRSF007860; VPS11; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR007860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008311};
KW Vacuole {ECO:0000256|PIRNR:PIRNR007860};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 858..893
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 815..849
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 962 AA; 108459 MW; 8E421A35DD81C90C CRC64;
MYQWRKFEFF EEKYGGKSKI PEDVSGNINC CSSGRGKVVI GSDEGHVSLL DRGLHFNFSF
LAHSSSVLFL QQLKQRNFLV TVGEDEQIAP QQSAMCLKVF DLDKMQPEGT SSIVPDCIGI
LRIFTNQFPH AKITSFLVLE EAPPILLIAI GLDNGCIYCI KGDIARERIT RFKLQIDNNN
VSDKSSSSIT GLGFRVDGQA LQLFAVSPNS VSLFSLQSQP PRRQLLDQIG CNVNSVAMSD
RSELIIGRPE AVYFYEVDGR GPCWAFEGEK KFVGWFRGYL LCVIGDQRSG KDTFNIYDLK
NRLIAHSLAV KEVSHMLCEW GNIILIMNDK SALCIGEKDM ESKLDMLFKK NLYTVAINLV
QSQQADAAAT AEVLRKYGDH LYSKQDYDEA MAQYISTIGH LEPSYVIQKF LDAQRIYNLT
NYLENLHEKG LASKDHTTLL LNCYTKLKDV DKLNVFIKSE DGVGEHKFDV ETAIRVCRAA
NYHEHAMYVA KKAGRHELYL KILLEDLGRY DEALQYISSL EPSQAGVTVK EYGKILIEHK
PAETIEILMR LCTEDGESAK RGSSSGAYLS MLPSPVDFLN IFIHHPQSLM NFLEKYTDKV
KDSPAQVEIH NTLLELYLSN EMNFPAVSQA SNGVDISLQA KSGAGRKSKA KSNGKVIADR
KDIYKEKDRV ERQEKGLLLL KSAWPADQEH PLYDVDLAII LSEMNAFKEG LLYLYEKMKL
YKEVIACYMQ AHDHEGLIAC CKRLGDSSKG GEPSLWADLL KYFGELGEDC SKEVKEVLTY
IERDDILPPI IVLQTLSRNP CLTLSVIKDY IARKLEQESK LIEEDRQAID KYQEDTLAMR
KEIHELRTNA RIFQLSKCTA CTFTLDLPAV HFMCMHSFHQ RCLGDNEKEC PECAPEYRAV
MEMKRSLEQN SKDQDQFFQL VKGSKDGFSV IAEYFGKGII SKTSNGTSGA LRSGSTSSSS
GF
//
