ID B9U0R4_CRYGA Unreviewed; 193 AA.
AC B9U0R4;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:ACB41938.1};
DE Flags: Fragment;
GN Name=IDE1 {ECO:0000313|EMBL:ACB41938.1};
OS Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=552467 {ECO:0000313|EMBL:ACB41938.1};
RN [1] {ECO:0000313|EMBL:ACB41938.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5032738 {ECO:0000313|EMBL:ACB41939.1}, F2863
RC {ECO:0000313|EMBL:ACB41947.1}, Joe {ECO:0000313|EMBL:ACB41941.1}, LA1
RC {ECO:0000313|EMBL:ACB41938.1}, LA175 {ECO:0000313|EMBL:ACB41945.1},
RC LA584 {ECO:0000313|EMBL:ACB41946.1}, TP0688
RC {ECO:0000313|EMBL:ACB41943.1}, TP1414 {ECO:0000313|EMBL:ACB41944.1},
RC and WM179 {ECO:0000313|EMBL:ACB41940.1};
RX PubMed=19517012; DOI=10.1371/journal.pone.0005862;
RA Ngamskulrungroj P., Gilgado F., Faganello J., Litvintseva A.P., Leal A.L.,
RA Tsui K.M., Mitchell T.G., Vainstein M.H., Meyer W.;
RT "Genetic diversity of the Cryptococcus species complex suggests that
RT Cryptococcus gattii deserves to have varieties.";
RL PLoS ONE 4:E5862-E5862(2009).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; EU408581; ACB41938.1; -; Genomic_DNA.
DR EMBL; EU408582; ACB41939.1; -; Genomic_DNA.
DR EMBL; EU408583; ACB41940.1; -; Genomic_DNA.
DR EMBL; EU408584; ACB41941.1; -; Genomic_DNA.
DR EMBL; EU408586; ACB41943.1; -; Genomic_DNA.
DR EMBL; EU408587; ACB41944.1; -; Genomic_DNA.
DR EMBL; EU408588; ACB41945.1; -; Genomic_DNA.
DR EMBL; EU408589; ACB41946.1; -; Genomic_DNA.
DR EMBL; EU408590; ACB41947.1; -; Genomic_DNA.
DR AlphaFoldDB; B9U0R4; -.
DR MEROPS; M16.020; -.
DR VEuPathDB; FungiDB:CGB_D1300C; -.
DR VEuPathDB; FungiDB:CNBG_4635; -.
DR VEuPathDB; FungiDB:I306_01873; -.
DR VEuPathDB; FungiDB:I308_04444; -.
DR VEuPathDB; FungiDB:I311_02542; -.
DR VEuPathDB; FungiDB:I314_04542; -.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 1.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..101
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 129..177
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACB41938.1"
FT NON_TER 193
FT /evidence="ECO:0000313|EMBL:ACB41938.1"
SQ SEQUENCE 193 AA; 22444 MW; 08E24BCC1D4AB8E8 CRC64;
EHLLFMGTKT HPSENAYQQY LSSHNGHSNA WTAMTSTNYY FDVSPDALEG ALDRFSGFFS
EPLFNEDCTE REIKAVDSEH KKNLQNDVWR FYQLEKHLSK PGHPYGKFGT GNYESLWSVP
KEAGRDPRRQ LIEWWEKEYC ARRMKLAVAG KEDVDTLEKW VKEKFENVPV RTEGKPEVGR
EGVRVVFDES PYG
//
