ID B9UEB2_9HIV1 Unreviewed; 296 AA.
AC B9UEB2;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACF37604.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACF37604.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACF37604.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACF37604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=314-40 {ECO:0000313|EMBL:ACF37604.1};
RX PubMed=18931623; DOI=10.1097/QAI.0b013e31818a6561;
RA Brennan C.A., Bodelle P., Coffey R., Devare S.G., Golden A., Hackett J.Jr.,
RA Harris B., Holzmayer V., Luk K.C., Schochetman G., Swanson P.,
RA Yamaguchi J., Vallari A., Ndembi N., Ngansop C., Makamche F., Mbanya D.,
RA Gurtler L.G., Zekeng L., Kaptue L.;
RT "The Prevalence of Diverse HIV-1 Strains Was Stable in Cameroonian Blood
RT Donors From 1996 to 2004.";
RL J. Acquir. Immune Defic. Syndr. 0:0-0(2008).
RN [2] {ECO:0000313|EMBL:ACF37604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=314-40 {ECO:0000313|EMBL:ACF37604.1};
RA Brennan C.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU618145; ACF37604.1; -; Genomic_RNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 11..52
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 62..212
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 231..278
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 231..278
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF37604.1"
SQ SEQUENCE 296 AA; 33063 MW; 7D58CF7872B9280A CRC64;
SSGIRKVLFL DGIDKAQEEH ERYHSNWRAM ASDFNLPPIV AKEIVASCDK CQLKGEAMHG
QVDCSPGIWQ LDCTHLEGKV ILVAVHVASG YVEAEVIPAE TGQETAYFLL KLAGRWPVKV
IHTDNGSNFT SAAVKAACWW ANITQEFGIP YNPQSQGVVE SMNKELKKII GQVRDQAEHL
KTAVQMAVFI HNFKRKGGIG GYSAGERIID IIASDMQTKE LQKQITKIQN FRVYFRDSRD
PIWKGPAKLL WKGEGAVVIQ DNNEIKVVPR RKAKIIRDYG KQMAGDDCVA GRQDED
//
