ID B9UN14_ORENI Unreviewed; 366 AA.
AC B9UN14;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=3beta-hydroxysteroid dehydrogenase type II {ECO:0000313|EMBL:ACJ24595.1, ECO:0000313|EMBL:ACJ24596.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|EMBL:ACJ24595.1};
RN [1] {ECO:0000313|EMBL:ACJ24595.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary {ECO:0000313|EMBL:ACJ24595.1};
RX PubMed=19084575; DOI=10.1016/j.mce.2008.11.008;
RA Senthilkumaran B., Sudhakumari C.C., Wang D.S., Sreenivasulu G.,
RA Kobayashi T., Kobayashi H.K., Yoshikuni M., Nagahama Y.;
RT "Novel 3beta-hydroxysteroid dehydrogenases from gonads of the Nile tilapia:
RT phylogenetic significance and expression during reproductive cycle.";
RL Mol. Cell. Endocrinol. 299:146-152(2009).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; EU827281; ACJ24595.1; -; mRNA.
DR EMBL; EU827282; ACJ24596.1; -; mRNA.
DR RefSeq; NP_001266602.1; NM_001279673.1.
DR AlphaFoldDB; B9UN14; -.
DR GeneID; 100534450; -.
DR KEGG; onl:100534450; -.
DR CTD; 80270; -.
DR OrthoDB; 3675908at2759; -.
DR BRENDA; 1.1.1.51; 4429.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF564; 3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 11..283
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 366 AA; 41718 MW; 225B1F9D2186E6A0 CRC64;
MSENQRGLVY LITGGCGFLG QHLLRILLEK EDRLEEIRVF DKRVDPTLND LSTERTRVVV
IQGDITDYKS VLEASHGADV VIHTASLVDV WYKVPEPLIY SVNVTGTKNV IKACVECGIE
CLLYTSSMEV VGPNVNGDHF KRGNEDTPYT VKHSMAYPKS KSEAEKIVLD ANGTKVKGGK
RLYTCSLRPT GIYGEWHQLM KDFYKQGVQR GGLIVGGIPD HVEHGRVYAG NVAWMHLLAA
RALRERPEKV GGEAFYCYDD SPYKSYEDFN LVLFSEFNFR KARIPTLVLW FLAMFNDLMH
WLLKPIHNYT PLLNSYTLAV VSTTFTVSTD KAERYFDYRP LYTWEECLAR TKKWIGTFPS
ENPKDC
//