ID B9UXM1_HALHO Unreviewed; 525 AA.
AC B9UXM1;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=4,4'-diaponeurosporene oxygenase {ECO:0000256|ARBA:ARBA00039159};
DE AltName: Full=4,4'-diaponeurosporene oxidase {ECO:0000256|ARBA:ARBA00041900};
DE AltName: Full=Carotenoid oxidase {ECO:0000256|ARBA:ARBA00042619};
GN Name=crtNb {ECO:0000313|EMBL:ACM07427.1};
OS Halobacillus halophilus (Sporosarcina halophila).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX NCBI_TaxID=1570 {ECO:0000313|EMBL:ACM07427.1};
RN [1] {ECO:0000313|EMBL:ACM07427.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 2266 {ECO:0000313|EMBL:ACM07427.1};
RA Koecher S., Saum S.H., Pfeiffer F., Palm P., Oesterhelt D., Muller V.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACM07427.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 2266 {ECO:0000313|EMBL:ACM07427.1};
RX PubMed=18820900; DOI=10.1007/s00203-008-0431-1;
RA Kocher S., Breitenbach J., Muller V., Sandmann G.;
RT "Structure, function and biosynthesis of carotenoids in the moderately
RT halophilic bacterium Halobacillus halophilus.";
RL Arch. Microbiol. 191:95-104(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-
CC diaponeurosporenal + 2 A + 3 H2O; Xref=Rhea:RHEA:56104,
CC ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:62743, ChEBI:CHEBI:79065;
CC Evidence={ECO:0000256|ARBA:ARBA00035945};
CC -!- PATHWAY: Carotenoid biosynthesis; staphyloxanthin biosynthesis;
CC staphyloxanthin from farnesyl diphosphate: step 3/5.
CC {ECO:0000256|ARBA:ARBA00037901}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtP subfamily. {ECO:0000256|ARBA:ARBA00038194}.
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DR EMBL; FJ040212; ACM07427.1; -; Genomic_DNA.
DR AlphaFoldDB; B9UXM1; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014105; Carotenoid/retinoid_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02734; crtI_fam; 1.
DR PANTHER; PTHR43734:SF7; 4,4'-DIAPONEUROSPORENE OXYGENASE; 1.
DR PANTHER; PTHR43734; PHYTOENE DESATURASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Carotenoid biosynthesis {ECO:0000256|ARBA:ARBA00022746,
KW ECO:0000256|RuleBase:RU362075};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362075}.
FT DOMAIN 48..518
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 525 AA; 59022 MW; B9C20AFA2B0AD2FA CRC64;
MAVLFHPRVY RFAYFNYDFL DDGTYQGKIL SVERKVLRMK VAIVGGGLGG LSAAVTLAKA
GAEVNLFEKN DHFGGKMMPV NEAGYHFDFG PNTITMPEAF QDVLRQGGLE KELSFTKLTH
HTRNQFKDGT IFDLSSDRQY MKQQLYRLDQ KGFQNYDAFL LEIERLFHLS KEYFLHRTFS
GWKDYLSPSL AKGFAQVRPL ESMDHFFRRY FSHPGIIQSL NRYSTYVGSN PYVTPATFAM
IAHLELNDGV YYVPGGNTKI AENMANAAEN QGAQLYKNTR VEKILTHNKQ ATGVMAGGHT
YEADYVIVNG DLLQSVPELI DNEKRASLSD KKIRSFDPSI SAFVIMAGLD TTMPDLHHHH
VLFSRNYEKE FSSLKNGQYP EEPTIYIGTS AKSDSTLSSE GDNCFILVNA PALGTSTEID
RERYKEKIYE DLAHSGLPIK NHVSFEKVIG PEEIESRFGA YRGSLYGPSS NRRLQAFMRP
FNQSQDFSNL YFCGGSTHPG GGSPMVVLSG QNVANQILGK IVHPE
//
