ID B9VIN1_9PICO Unreviewed; 2113 AA.
AC B9VIN1;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Human cosavirus E1.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Cosavirus; Cosavirus E.
OX NCBI_TaxID=589919 {ECO:0000313|EMBL:ACL99815.1, ECO:0000313|Proteomes:UP000202251};
RN [1] {ECO:0000313|EMBL:ACL99815.1, ECO:0000313|Proteomes:UP000202251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19102772;
RA Holtz L.R., Finkbeiner S.R., Kirkwood C.D., Wang D.;
RT "Identification of a novel picornavirus related to cosaviruses in a child
RT with acute diarrhea.";
RL Virol. J. 5:159-159(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; FJ555055; ACL99815.1; -; Genomic_RNA.
DR Proteomes; UP000202251; Genome.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1094..1259
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1446..1638
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1882..2000
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 563..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2113 AA; 234547 MW; A60BD88131735554 CRC64;
MGANNSKESV SSNGNQGTIV NNFYANQYYG SVDASAQGVG SDTTPENGTV SGFLGLAASA
FNAAGFLATP SAENSTNMGD RILTLREGNT AISSQATEGI LHGYNKETDT SQPTSCGDRA
SKATPATQRS FIIPLKDWTS SQNSYSALVY RTSHMSKDAV GNLFSKNMNT HAYTKTGWTA
TLQINTSPFH SGLIGLFMVP EFVRKISDDL EWIDLVAAGF NTTLFKDSNT YNQDSALVGK
IDDKNTFDLA STTPEQFFLY PHQLINPKET TMATVSVPYV NVAPSSDPSV HNIWTVVVMV
LSPLQIGSGA SPNVQMTLTL TPTGSVFNGL RHPKPAAQSP FPTRPFHHSF QFSSTVPDVT
EPCYGMTVVP PKDFMPAPIT DLVSLAKVPT FCTVTENKPY FEVNNNKSDA PVFQSNVVLS
DPHYAHTLVA GLGRYFGNYR GSLQFTLISA TTSMTRGKLL CCYTPPGADK PTTVEQAMMS
TYAIWDLGLQ STFEFVVPFI STVDFRVNVV STSSAVNVDG WFSIFKLNAL TYPANTPPNQ
HILVMLSGGS DFSYRLPIAP PFNLHSPDPE PHDNAEKGTS SNHDASLTGG HSVGIKVAHS
DTSFFFDRYR YIGTVESTKN TPATVATLTD TNGIIKSFNN LANADNGYKK VLMLAPNPSF
CGAAYTVFAM FDQTGTTGAK KRLLFGQGDY HLYRSCPFTY YTADLEVTVV PDAGVAGPWR
VTWLPVGAPL DEIEMITSET SNPQSWSFFT EDRKDSSSLY SLNPTFWSND QNKVSFDIPM
TTPLTLLPLY FDGYPDYSNT KGLYGVAPAN GFGNIVVKSN TLADKFMVYI RYKNFRGYVP
RPLPRLVQPN PSSRVRMAAS DGLAPRKYLS YRKIQLSGDV ETNPGPNFSK FCVQGPTSDF
IRLVRDPETL DNVNRLLSTL NNLMAKWNSF KHMCLDSYFL RDILCLLTKL TALGFLVHNQ
GPSAYLAAAA ILISDGISFL DWYDKIKRFM SRRLRISPPP FCLAQGLDLR DVVTFFNAAK
GAQWMVDSIR SLIRWIKQWL ELEEENEAVQ FEKMLVDSPK HCKAINDYNV GKTFVRPENS
FDFMDKLVDS ATKLGRVNIA SYFRSFTSVD TDAPRMEPVV LVLRGKPGAG KSAAATVIAA
AVSKTLTGTQ SVYTLSPDTE HMDGYHGQFS MIMDDLGQNP DGEDFRTFCQ MISCAQYRPS
MADLRDKGIL FKSQFIIATT NLPEFRPLTI SDRGAVERRI TFDIGVTPGS AATRNGKLDL
AIALKPDGPG EFPYNCDCQL LHTTGLALQN LRSGKTMNLK ELVDMIVKKI KSKRTTSGML
EGLVMQSPKI VGYTKDDEGV VIVDCLEEWN KIKDKKRKQQ ALEMVAEEIK VQHEKHRETV
NLLKMFLSGL GVVAAVGAAL AAGAYLKSET AGKAVDEPDT KKEEETKTEG PYNGPSKKDL
KTLKLKAQSP LLDLEKKIMN NVQPFVMRFG NREYVQSCLF VGKRVFLVNK HAIETVEERF
SVAGTEYNID DVEIAILDTE YGLTDVAAVK ISNGPEWKNL SKLFLNLETE LLPGTRITVL
SNDNINMLRE GSFLRYEEEI PTNIGPIPFV MLYKASSYFG MCGSAVVTRF GDSSGILGIH
CAGGGGVSVA SRVTRKMVET VLEYFYPPQV QGLIIKEEIG ERVHVPRQSK LKRTHATYPA
TKDYGPAVLS KNDPRLNPGV DFDSVIFSKH VNNVVIDKDT SIWQSLKLAA QVYAQRLKNI
DKEPLTVEEA IAGIPGLDRL DPKTASGLPY KKTRKQMIDF QKCEITDDQL KCRLGMWLAG
RKPETLYQTF LKDEIRPIEK VKAGKTRIID VTPLDHVLAF RIVMGRFMAG FHQNHGFKLG
SAVGCDPDVA WANYGFKLGG FKYQYDFDYS NFDASHSESI FEVLKEFIFT PDNGFDQRCS
LMIDSLVESV HCYEDKRITI RGGLPSGTAG TSIINTIINN IILHAAFYYT YSNFEWDDLQ
MLAYGDDIVA ASDHELDLDR IKDFMARIGY KITPADKGET FTPKSMKDIQ FLKRRFRKIA
GIWAPVMEIS NLQAMLSWYK PGTLNEKLES VSRLAHFCGE EEYNELFKPF VEDGFDIKPW
KQLHLEWLNK FTG
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