ID B9VTD0_9SALA Unreviewed; 228 AA.
AC B9VTD0;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ACM67198.1};
OS Speleomantes genei (Sardinian cave salamander).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Plethodontidae; Plethodontinae;
OC Speleomantes.
OX NCBI_TaxID=36318 {ECO:0000313|EMBL:ACM67198.1};
RN [1] {ECO:0000313|EMBL:ACM67198.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13 {ECO:0000313|EMBL:ACM67198.1}, 15
RC {ECO:0000313|EMBL:ACM67199.1}, and 16 {ECO:0000313|EMBL:ACM67200.1};
RX PubMed=19136065; DOI=10.1016/j.ympev.2008.12.011;
RA van der Meijden A., Chiari Y., Mucedda M., Carranza S., Corti C., Veith M.;
RT "Phylogenetic relationships of Sardinian cave salamanders, genus
RT Hydromantes, based on mitochondrial and nuclear DNA sequence data.";
RL Mol. Phylogenet. Evol. 51:399-404(2009).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; FJ602211; ACM67198.1; -; Genomic_DNA.
DR EMBL; FJ602212; ACM67199.1; -; Genomic_DNA.
DR EMBL; FJ602213; ACM67200.1; -; Genomic_DNA.
DR AlphaFoldDB; B9VTD0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 116..223
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 124..191
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 169..220
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 179..222
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACM67198.1"
FT NON_TER 228
FT /evidence="ECO:0000313|EMBL:ACM67198.1"
SQ SEQUENCE 228 AA; 25634 MW; 153ECFEB31C95FF8 CRC64;
AAPMKEVSLR AQGSLAYPGL RTHGTLEGIG GSKTSSRGGL SSLADTFEQV IEDILEDEQS
MRPSEENKDA DLFTPRVMLS SQVPLEPPLL FLLEEYKNYL DAANMSMRVR RHSDPARRGE
LSVCDSISEW VTASDKKTAV DMSGQTVTVL EKVPVSKGQL KQYFYETKCN PMGYMKEGCR
GIDKRYWNSQ CRTTQSYVRA LTVDNKKKVG WRFIRIDTSC VCTLTIKR
//
