ID B9VUV4_BUBBU Unreviewed; 904 AA.
AC B9VUV4;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|EMBL:ACM68434.2};
GN Name=TLR3 {ECO:0000313|EMBL:ACM68434.2};
OS Bubalus bubalis (Domestic water buffalo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bubalus.
OX NCBI_TaxID=89462 {ECO:0000313|EMBL:ACM68434.2};
RN [1] {ECO:0000313|EMBL:ACM68434.2}
RP NUCLEOTIDE SEQUENCE.
RA Banerjee P., Joshi J., Mahajan P., Mishra B., Vijh R.K., Tantia M.S.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ606788; ACM68434.2; -; Genomic_DNA.
DR AlphaFoldDB; B9VUV4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 7.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACM68434.2};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002893486"
FT TRANSMEM 705..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 754..897
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 904 AA; 103617 MW; 0B3707C81410F32F CRC64;
MSRPLPYHIY FFTGLLTCWI LCTSSAHKCT VRHEVADCSH LKLTQIPDDL PTNITVLNLT
HNQLRRLPPA NFTRYSQLTI LDGGFNSISK LEPELCQSLP WLEILNLQHN EISQLSDKTF
IFCMNLTELH LMSNSIQKIK NDPFKNLKNL IKLDLSHNGL SSTKLGTQLQ LENLQELLLS
NNKISSLAPE ELDFLGNSSL KRLELSSNQI KEFSPGCFHA IGKLSGLSLN NAKLSPSLTE
KLCLELSNTS IENLSLNSNQ LDTISHTTFD GLKQTNLTTL DLSRNSLRVM GNDSFAWLPH
LEYLSLEYNN IEHLSSRSFY GLSNLTHLDL RRSFTRQSIS LTSLPKNDDF SFQWLKCLEY
LNMEDNNFPG IKRNTFTGLV RLKFLSLSNS FSSLRTLTNE TFLSLAGCPL LLLNLTKNKI
SKIQSGAFSW LGHLEVLDLG LNEIGQELTG QEWRGLDNIV EIYLSYNKYL ELTTNSFTSV
PSLQRLMLRR VALKNVACSP SPFRPLPNLV ILDLSNNNIA NVNDELLKGL EKLEILDLQH
NNLARLWKHA NPGGPVQFLK GLSHLRILNL GSNGFDEIPV EAFKDLRELK SIDLGMNNLN
ILPQSVFDNQ VSLKSLSLQK NLITSVQKTV FGPAFRNLSY LDMRFNPFDC TCESIAWFVN
WINSTHTNIS ELSNHYLCNT PPQYHGFPVM LFDVSPCKDS APFELLFMIN TNILLIFIFI
VLLIHFEGWR ISFYWNVSVH RVLGFKEIDR AEQFEYAAYI IHAYKDRDWV WKHFSPMEEE
DHTLRFCLEE RDFEAGVLEL EAIVNSIRRS RKIIFVITQN LLKDPLCKRF KVHHAVQQAI
EQNLDSIILI FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERVNAFH HKLKVALGSR
NSVH
//
