ID B9W858_CANDC Unreviewed; 437 AA.
AC B9W858;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Chromatin-associated transcriptional (Elongation) factor, putative {ECO:0000313|EMBL:CAX44899.1};
GN OrderedLocusNames=Cd36_06180 {ECO:0000313|CGD:CAL0000159682};
GN ORFNames=CD36_06180 {ECO:0000313|EMBL:CAX44899.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX44899.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX44899.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription.
CC {ECO:0000256|ARBA:ARBA00037349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; FM992688; CAX44899.1; -; Genomic_DNA.
DR RefSeq; XP_002417278.1; XM_002417233.1.
DR AlphaFoldDB; B9W858; -.
DR GeneID; 8044818; -.
DR KEGG; cdu:CD36_06180; -.
DR CGD; CAL0000159682; Cd36_06180.
DR VEuPathDB; FungiDB:CD36_06180; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_0_1_1; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000002605; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 248..325
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 50516 MW; CCB0E0DEC35F0EE1 CRC64;
MKRQKNEKEK KKINKPKQNY QSLQSFDQYN KLNTEMSDPL ADYTNLSHDE IDPSTANVAE
SQQPEPEQQV SEHQEPQQQE LTYENDENVL SSIKVEKVTN GEEMGDIVRK KLIRNSRPQE
HEQDDFNDNS NVTSGSRPSL SQQQTDEIDI ANMDPQQRKR FELEERMSAA IKSTNKRRRK
ADEDDLERMQ DDKIDYLKDQ MIKAANSDVE KNSQGQIATE KLKLLREVTD ILARADLAIP
ILDNNLLEAV RLWLEPLPDA SMPAYQIQKE LIHALETLPI KTDHLVASGI GKVLVFYQRS
KRTEPSLKKI VDRLIGDWTR PILNKSDSYK DRTVQFHEYN RNKFTNKLSR GVKRKEAKTL
YEENAERRKR AAIPSTRTTA YKIAPQVDKS LLMRQQARHA SNDERFKRIN SKLTSMSVKR
KAAKKGGPSI EGRDLAM
//
