ID B9WA92_CANDC Unreviewed; 697 AA.
AC B9WA92;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=X-Pro aminopeptidase, putative {ECO:0000313|EMBL:CAX43311.1};
GN OrderedLocusNames=Cd36_15330 {ECO:0000313|CGD:CAL0000165861};
GN ORFNames=CD36_15330 {ECO:0000313|EMBL:CAX43311.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX43311.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX43311.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; FM992689; CAX43311.1; -; Genomic_DNA.
DR RefSeq; XP_002418012.1; XM_002417967.1.
DR AlphaFoldDB; B9WA92; -.
DR MEROPS; M24.A10; -.
DR GeneID; 8046526; -.
DR KEGG; cdu:CD36_15330; -.
DR CGD; CAL0000165861; Cd36_15330.
DR VEuPathDB; FungiDB:CD36_15330; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_6_1; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000002605; Chromosome 2.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:CAX43311.1};
KW Hydrolase {ECO:0000313|EMBL:CAX43311.1};
KW Protease {ECO:0000313|EMBL:CAX43311.1}.
FT DOMAIN 72..214
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 406..622
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 632..693
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 697 AA; 78872 MW; B476EE1737E5B577 CRC64;
MSSRVARAQC ANCTCSPGLI SRANRKSIYK RLSLNRRDST PTSGCTSREG SIFTFNPSLC
LPDAKEVNTS KRLESLRKQM KEHDLGIYIV PSEDQHQSEY VSAYDQKRSF ISGFSGSAGI
AIITRDMNSV GDTFEGTAAL STDGRYFTQA VDELDFNWIL LKQGAKDEPN WKEWTVQQAV
QLSLDSGIAV RIGVDPTLIT YKLYKEFQSI VEKELTKNEK VKIEFTAVKE NLINKIWEQF
EELPPRNLGE IKSLDVNFTG RNVEDKLADV KKHLTGDIKG IVISALDEVA WLLNLRGSDI
QYNPVFYSFV ILTDESTTLY IGENRLSEDI VGDLKTAGIN IEPYESFYPS LTTVSTKLSE
SNKKFYIPDN ANWEVVRNLK CEFTQGLSPV EDLKAVKNNV ELEGAKIAHL KDGRALIKFF
AWLEEQVIEK QELIDEIEAD EKLTEFKQQE DNFVGLSFDT ISATGANGAV IHYKPTKGQC
STINPRKLYL NDSGSQFLEG TTDVTRTVHF QKPTKEEITN YTLVLKGNIA LSTLRFPQNT
TGNLIDAIAR QYLWKYGLNY AHGTSHGVGA YLNVHEGPIG IGPRPNAAAY ALKAGNLISN
EPGYYQEGDY GIRIENVMFI KESDLRYDGK SYLEFETVTK VPYCRRLIGI HLLNDEEISW
INEYHADIWN SFHENFDKNS YTYKWLKRET EPLVKSK
//
